AuTophaGy related 1 (Atg1) is a 101.7kDa serine/threonine kinase in S.cerevisiae, encoded by the gene ATG1. [1] . It is essential for the initial building of the autophagosome and Cvt vesicles. In a non-kinase role it is - through complex formation with Atg13 and Atg17 - directly controlled by the TOR kinase, a sensor for nutrient availability.

2023年1月12日 · In recent years, much progress has been made in understanding the functions of individual ATG genes as well as their roles in disease and physiology. The molecular functions of key players have...

Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1.

2019年1月10日 · The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in genes that control autophagy and human disease, especially neurodegenerative, inflammatory ...

Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. [5] . This protein is characterized as a subunit of the autophagy -related ATG12- ATG5 /ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation.

2025年3月28日 · ATG7 (Autophagy Related 7) is a Protein Coding gene. Diseases associated with ATG7 include Spinocerebellar Ataxia, Autosomal Recessive 31 and Fatty Liver Disease 1. Among its related pathways are Autophagy and Class I …

自噬的整个过程中, 时刻都受到不同的 自噬相关基因 (autophagy-related gene, ATG)的调控, 大约已有38个自噬相关基因被发现。 这些基因在酵母和哺乳动物高度保守, 是自噬发生必不可少的分子，参与了自噬发生的不同阶段。

To date, several key factors regulating this intracellular degradation process have been identified. The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response.

2017年9月13日 · Autophagy is mediated by dozens of autophagy-related (Atg) proteins, among which Atg4 is the sole protease that regulates autophagy through the processing and deconjugating of Atg8. As the Atg4...

The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG) proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is paradigmatic of studying autophagy deficiency, yet emerging data suggest that ...