自噬的整个过程中, 时刻都受到不同的 自噬相关基因 (autophagy-related gene, ATG)的调控, 大约已有38个自噬相关基因被发现。 这些基因在酵母和哺乳动物高度保守, 是自噬发生必不可少的分子，参与了自噬发生的不同阶段。

2019年3月25日 · Atg2 bridges highly curved liposomes, thereby facilitating efficient phospholipid transfer in vitro, a function that is inhibited by mutations that impair autophagosome formation in vivo. These...

Autophagosome formation is considered to take place on the endoplasmic reticulum and involves functions of autophagy-related (Atg) proteins. Here, we report the identification and characterization of mammalian Atg2 homologues Atg2A and Atg2B.

Recent advances in structural and biochemical analyses have been applied to Atg2 and have revealed it to be a novel multifunctional protein that tethers membranes and transfers phospholipids between them.

2024年8月2日 · Autophagy-related proteins (ATGs) 2A and 9A have an essential role in autophagy by mediating lipid transfer and re-equilibration between membranes for autophagosome formation.

2019年4月16日 · Recent advances in structural and biochemical analyses have been applied to Atg2 and have revealed it to be a novel multifunctional protein that tethers membranes and transfers phospholipids between them.

2019年6月3日 · Here we show that the autophagy protein, ATG2, without a clear function since its discovery over 20 yr ago, is in fact a lipid-transfer protein likely operating at the ER-autophagosome interface. ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro.

2021年8月1日 · Recent structural and biochemical analyses have revealed that two mysterious autophagy-related (Atg) proteins, Atg2 and Atg9, are novel types of intermembrane and interleaflet lipid transporters, respectively. This review summarizes recent discoveries surrounding Atg2 and Atg9 as a lipid transporter and discusses the molecular mechanism of ...

2019年6月6日 · Here we show that the autophagy protein, ATG2, without a clear function since its discovery over 20 yr ago, is in fact a lipid-transfer protein likely operating at the ER–autophagosome interface. ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro.

2020年6月4日 · 该研究主要通过生物化学和结构生物学等手段，揭示了WIPI蛋白识别、结合ATG2并调控自噬体形成的分子机制。 自噬是真核细胞中一种高度保守的自身降解途径。 自噬过程通过细胞内容物的降解和循环利用，在维持细胞内稳态平衡、避免有害蛋白聚集体积累以及抵御病原入侵等方面都发挥着重要作用。 WIPI蛋白家族是自噬起始信号PI3P脂质的效应分子，其可以招募其他因子对自噬体形成进行调控。 WIPI家族蛋白可以特异性识别ATG2蛋白中的一段线性序 …