于是作者通过测量 Xbp1s （由IRE1介导的剪接Xbp1转录本）和Hspa5（ATF6目标基因）的总体种群水平表达来监测IRE1和ATF6的活性。研究人员验证了Xbp1s和Hspa5在Tm处理开始后的12 …

2017年10月13日 · We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein …

2018年1月5日 · Our study unravels the first ATF6-regulated gene expression network related to homeostatic regulation of membrane organelles, and provides novel mechanistic insights into …

2019年1月14日 · Here we show, using a mouse model of myocardial ischemia/reperfusion, that selective pharmacologic activation of the ATF6 arm of the unfolded protein response (UPR) …

ATF6(N) is a basic leucine zipper (bZIP)–class transcriptional activator that, once untethered from the membrane, migrates to the nucleus to up-regulate ER protein–folding chaperones and …

Here, we analyzed ATF6, a type II transmembrane glycoprotein that serves as a sensor/transducer of the unfolded protein response, as a potential ERAD-Lm substrate in …

E, increase of IRE1 protein levels in response to 3 μ m Tm in ATF6-KD and scram cells over time. SH-SY5Y cells were transduced with vectors encoding shRNA against ATF6 or scrambled …

2000年9月1日 · ATF6 bound the ATF6m1 site significantly more weakly than the ATF6 site (Fig. 3 B, lanes 1 and2), suggesting that the G flanking the TGACGT core is critical to ATF6-specific …

6 天之前 · We found the ATF6 branch of the UPR significantly activated in the TM + CO group as evidenced by the increased expression of BiP, ATF6, and nuclear ATF6 p50 (Fig. 2e, f).

2018年1月11日 · 该研究首次绘制了多种人干细胞和体细胞受内质网应激蛋白ATF6调控的基因表达图谱，揭示了ATF6维持多种细胞器稳态的新型机制，为衰老和老年性疾病的研究和干预提供 …