Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene [5][6][7] and is involved in the unfolded protein response. ATF6 is an …

2025年3月28日 · ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 and Achromatopsia. Among its related …

2024年3月15日 · Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, …

Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in …

ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress.

ATF6 is a transcriptional regulator of the mammalian UPR and is activated by regulated proteolysis. Interestingly, as ATF6 induces Xbp-1 mRNA expression, coping with ER stress at …

ATF6 Is Activated by Ischemia/Reperfusion and Is Protective. Soon after the ATF6-MER transgenic mice were developed they were used to determine the role for activated ATF6 in …

ATF6 is an ER-membrane-bound transcription factor activated by ER stress-induced proteolysis which consists of two closely related factors, ATF6alpha and ATF6beta, in mammals. …

2018年10月19日 · Cardiac myocyte-specific deletion of Atf6 (ATF6 cKO [conditional knockout]) blunted transverse aortic constriction and exercise-induced cardiac myocyte hypertrophy and …

In high glucose culture, beta cell proliferation, but not apoptosis, was increased by overexpression of ORMDL3 levels, likely mediated by its downstream factor ATF6. Mechanistically, ORMDL3 …

2018年8月6日 · Tam et al. find that dihydrosphingosine and dihydroceramide, early sphingolipid intermediates, directly activate the mammalian UPR sensor ATF6, via a domain distinct from …

2018年5月25日 · Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a major regulator of …

6 天之前 · ATF6 promotes cancer chemoresistance by enhancing survival under stress conditions. It interacts with STAT3, NOTCH1, MAPK, and lysosomal pathways, driving …

ATF6 is an endoplasmic reticulum (ER) transmembrane transcription factor that is activated by the ER stress/unfolded protein response by cleavage of its N-terminal half from the membrane. …

2017年10月13日 · We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein …

We constructed a dynamic model to describe the adaptive UPR signaling network, for which incorporation of all three branches was required to match the data. Our calibrated model …

ATF6 is a key transcriptional activator of the unfolded protein response (UPR), which allows mammalian cells to maintain cellular homeostasis when they are subjected to a variety of …

6 天之前 · ATF6 operates as a basic-leucine zipper (bZIP) transcription factor that binds to the consensus ER stress response element (ERSE), regulating the transcription of genes involved …

In response to endoplasmic reticulum (ER) stress, activating transcription factor 6 (ATF6), an ER membrane-anchored transcription factor, is transported to the Golgi apparatus and cleaved by …

The ChIP-seq results showed that p-STAT3 (Tyr705) protein directly binds with ATF6 promoter, suggesting that STAT3 has a direct regulatory effect on ATF6 in neurons, thus explaining the …