随后，ang ii与其1型受体(at1r)相互作用，通过 at1受体 刺激血管收缩、口渴、交感神经系统活动和 醛固酮 分泌，协同增加外周血管阻力、 钠潴留 、血容量和全身血压[1]。ras的失调通常在高血压、心力衰竭、心肌梗死、中风或慢性肾脏疾病等疾病中观察到。

Angiotensin II receptor type 1 (AT1) is a G q/11 -coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene. AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system.

血管紧张素受体主要包括1型受体（angiotensin type 1 receptor, AT1 receptor）和2型受体（angiotensin type 2 receptor, AT2 receptor），此外还有3型和4型受体。AT1R和AT2R仅有约30%的序列相同，但血管紧张素II作为其主要配体，与二者有相近的亲和力。

2018年3月26日 · Ang indicates angiotensin; AT1R, angiotensin receptor type 1; HB-EGF, heparin-binding EGF-like growth factor; and TACE, tumor necrosis factor-α converting enzyme. Involvement of Caveolin 1 in Angiotensin II–Induced Vascular Remodeling

AT 1 受体是被研究最清楚的血管紧张素受体。 AT 1 受体被血管紧张素II激活后，通过偶联的 G q/11 和 G i/o 激活 磷脂酶C （phospholipase C, PLC）并升高胞浆Ca 2+ 离子浓度，进而激活一系列细胞反应，如： 蛋白激酶C （protein kinase C，PKC）。 激活的受体亦能抑制 腺苷酸环化酶 （adenylate cyclase）或激活一些 酪氨酸激酶 （tyrosine kinase）。 [2]

The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy. FEBS Lett. 2005;579(7):1579–1586. doi: 10.1016/j.febslet.2005.01.068.

Ang II acts through two classic angiotensin receptors (ATRs), angiotensin receptor type 1 (AT1R) and angiotensin receptor type 2 (AT2R). ATRs belong to G-protein-coupled receptors that contain seven transmembrane domains and have molecular mass of 41 kDa.

2022年3月22日 · AT1R, a member of the G protein-coupled receptor (GPCR) family, modulates Ang II deleterious effects through the activation of multiple downstream signaling pathways, among which are MAP kinases (ERK 1/2, JNK, p38MAPK), receptor tyrosine kinases (PDGF, EGFR, insulin receptor), and nonreceptor tyrosine kinases (Src, JAK/STAT, focal adhesion ...

2020年9月18日 · The angiotensin II (AngII) type 1 receptor (AT1R), a member of the G protein-coupled receptor (GPCR) family, signals through G proteins and β-arrestins, which act as adaptors to regulate AT1R internalization and mitogen-activated protein kinase (MAPK) ERK1/2 activation. β-arrestin-dependent ERK1/2 regulation is the subject of important ...

Angiotensin II Receptor Type 1 (AT1) is a well-characterized G-protein-coupled receptor found in various tissues, including the brain. It plays a crucial role in neuroprotection following cerebral ischemia by mediating effects such as cell growth inhibition, neuronal regeneration, and modulation of cellular differentiation.