Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.

2025年3月18日 · Inspired by the squirrel tail, this study developed a novel FAP-targeted molecule, FSND 3, which is modified with three Asp–peptide adapters to enable both 68 Ga ( [68 Ga]Ga-FSND 3) and 18 F ( [18 F]AlF-FSND 3) PET imaging.

2013年3月1日 · Isomerization of aspartyl residues (Asp or D) is a common degradation pathway that leads to product heterogeneity in monoclonal antibodies (mAbs).1 This nonenzymatic reaction contains two major steps: (1) formation of a succinimide intermediate (Asu) resulting from the attack of the backbone amide of the n + 1 residue on the (γ-carbonyl of Asp (...

2011年5月25日 · A beta-aspartic acid (β-Asp) residue is an abnormal peptide linkage that presents in a polypeptide by inserting the carboxylic group originally on the side chain of alpha-aspartic acid (α-Asp) into the peptide backbone and leaving the …

RGD肽是一种细胞粘附序列，可以模仿细胞粘附蛋白并与 整合素 αVβ3 结合，并可用于 组织工程 中的合成支架，以增强细胞附着，模仿 体内 (in vivo)的条件。 [2] ^ Ruoslahti, Erkki; Pierschbacher, Michael D. Arg-Gly-Asp: a versatile cell recognition signal. Cell. 1986, 44 (4): 517–18. PMID 2418980. doi:10.1016/0092-8674 (86)90259-X.

2020年2月20日 · Aspartimide formation leads to low yields in addition to costly purification or even inaccessible peptide sequences. Here, we report an alternative approach to address this longstanding...

Formation of isoaspartic acid (isoAsp) is a common modification of aspartic acid (Asp) or asparagine (Asn) residue in proteins. Differentiation of isoAsp and Asp residues is a challenging task owing to their similar properties and identical molecular mass.

RGD peptides and mimetics, in addition to providing insights into the fundamental mechanisms of cell adhesion, are potential therapeutic agents for the treatment of diseases such as thrombosis and cancer. The tripeptide Arg-Gly-Asp (RGD) was originally identified as the sequence within fibronectin that mediates cell attachment.

2019年7月15日 · Aspartimide (Asi) formation is a notorious side reaction in peptide synthesis that is well characterized and described in literature. In this context, we observed significant amounts of chain termination in Fmoc-SPPS while synthesizing the N-terminal Xaa-Asp-Yaa motif. This termination was caused by the formation of piperazine-2,5-diones.

2011年11月11日 · Here we focus our attention on what could be considered the most documented and studied side reaction in peptide chemistry, namely aspartimide formation.