2025年3月28日 · ASH2L (ASH2 Like, Histone Lysine Methyltransferase Complex Subunit) is a Protein Coding gene. Diseases associated with ASH2L include Kleefstra Syndrome and Kabuki Syndrome 1. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and RNA Polymerase I Promoter Opening.

Human ASH2L genome location and ASH2L gene details page in the UCSC Genome Browser.

2022年12月13日 · Ash2l loss resulted in increased loading of histone H3 and reduced chromatin accessibility at promoters, accompanied by an increase of repressing and a decrease of activating histone marks....

2023年12月19日 · The trithorax protein ASH2L is essential for organismal and tissue development. As a subunit of COMPASS/KMT2 complexes, ASH2L is necessary for methylation of histone H3 lysine 4...

Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Contributes to Histone Methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation; positive regulation of cell population proliferation; and response to estrogen.

ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation. CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.

2020年11月30日 · Using a whole-genome CRISPR/Cas9 gene knockout approach, we identified ASH2L, a core component of the H3K4 methyl transferase complex, as a protein required for bleomycin sensitivity in L1236...

2023年8月20日 · ASH2L plays an important role in cell invasion and migration of TNBC cell lines. DNA and RBBP5 binding domains of ASH2L are critical for its oncogenic function. ASH2L cooperates with RBBP5 and WDR5 for TNBC cell invasion and migration. ASH2L is involved in the maintenance of global H3K4 mono- and tri-methylation.

2023年8月20日 · ASH2L (Absent-Small-Homeotic-2-Like protein) is a core subunit of the COMPASS (COMplex of Proteins ASsociated with Set1) complex, the most notable writer of the methylation of histone H3 lysine 4 (H3K4). The COMPASS complex regulates active promoters or enhancers for gene expression, and its dysfunc …

2019年7月16日 · Here we show that the COMPASS family histone methyltransferase co-factor ASH2L is required for maintaining neural progenitor cells (NPCs) and the production and positioning of projection neurons during neocortex development.