The Human SLC1A5 (ASCT2) Amino Acid Transporter: From …
2018年9月4日 · SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts. ASCT2 is an …
谷氨酰胺转运载体ASCT2在肿瘤中的研究进展 - 仁和软件
2018年8月15日 · 丙氨酸-丝氨酸-半胱氨酸转运载体2（alanine-serine-cysteine transporter 2, ASCT2）是Na + 依赖性的，主要通过跨膜转运谷氨酰胺及一些大分子中性氨基酸。 ASCT2在 …
ASCT2 (SLC1A5)-dependent glutamine uptake is involved in …
In this study, ASCT2, an amino acid transporter responsible for glutamine transport, in addition to LAT1 and GLS, is overexpressed in HNSCC and associated with poor survival.
人类SLC1A5（ASCT2）氨基酸转运蛋白：从功能到结构以及在细胞 …
ASCT2是丙氨酸，丝氨酸，半胱氨酸转运蛋白2的首字母缩写，即使优选的底物是条件必需氨基酸谷氨酰胺，而半胱氨酸是调节剂而不是底物。 关于细胞和组织中氨基酸转运的研究始于60年 …
Frontiers | The Human SLC1A5 (ASCT2) Amino Acid Transporter: …
2018年9月3日 · ASCT2 is an acronym standing for Alanine, Serine, Cysteine Transporter 2 even if the preferred substrate is the conditionally essential amino acid glutamine, with cysteine …
谷氨酰胺转运蛋白ASCT2的研究进展 - 仁和软件
谷氨酰胺必需通过细胞膜上特异性载体的转运才能进入细胞内发挥作用，其中Na + 依赖性谷氨酰胺载体2 (alanine-serine-cysteine transporter 2, ASCT2)最为重要。 ASCT2不仅在正常组织器官 …
ASCT2/SLC1A5 controls glutamine uptake and tumour growth …
2016年6月16日 · Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells. …
Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2 ...
2020年8月1日 · Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to solute carried (SLC) family transporters and is encoded by the SLC1A5 gene serves as a significant role for …
The role of ASCT2 in cancer: A review - ScienceDirect
2018年10月15日 · In this article, we have described the function of ASCT2 in different cancers and discussed the pharmacological inhibitors of ASCT2. As a potential target in abnormal …
Amino acid metabolism in tumor biology and therapy
2024年1月13日 · ASCT2(SLC1A5) is the main glutamine transporter in tumor (Fig. 1). It is regulated by multiple tumor associated transcription factors including Rb/E2F , androgen …