2018年11月9日 · AMPK phosphorylates Skp2 at S256 and promotes the integrity and E3 ligase activity of Skp2 SCF complex leading to K63-linked ubiquitination and activation of Akt and subsequent oncogenic processes. Importantly, AMPK-mediated Skp2 S256 phosphorylation promotes breast cancer progression in mouse tumor models, correlates with Akt and AMPK ...

AMPK is a highly conserved sensor of intracellular adenosine nucleotide levels that is activated when even modest decreases in ATP production result in relative increases in AMP or ADP. In response, AMPK promotes catabolic pathways to generate …

AMP触发的经典激活有三种具体机制：（1）促进LKB1 复合物对 Thr172 的磷酸化; (2) 抑制蛋白磷酸酶对Thr172 的去磷酸化; (3) 别构激活Thr172 磷酸化的 AMPK。 所有这三种效应都是由于 AMP 与 AMPK 的结合，而不是与上游激酶或磷酸酶的结合，这种三方机制确保系统以非常敏感的方式对 AMP 的小幅增加作出反应（ [1]: Trends Cell Biol. 2016）。 AMP通过三种效应激活AMPK。 Trends Cell Biol. 2016. ADP 的结合可以触发前两种机制，但大多数 AMPK 复合物对 AMP 的敏 …

2003年10月10日 · Because insulin is able to activate Akt and inactivate AMP-activated protein kinase (AMPK) in the heart, we hypothesized that Akt can regulate the activity of AMPK. To address the potential existence of this novel signaling pathway, we used a number of experimental protocols to activate Akt in cardiac myocytes and monitored the activation ...

2018年11月9日 · AMPK phosphorylates Skp2 at S256 and promotes the integrity and E3 ligase activity of Skp2 SCF complex leading to K63-linked ubiquitination and activation of Akt and subsequent oncogenic...

2018年3月14日 · In this study, we elucidate mechanisms that enable reversible matrix attachment by breast cancer cells. Matrix deprival triggered AMPK activity and concomitantly inhibited AKT activity by upregulating the Akt phosphatase PHLPP2.

2017年4月13日 · AMPK and AKT are two primary effectors in response to metabolic stress: AMPK acts as an energy-sensing factor which rewires metabolism and maintains redox balance. AKT broadly promotes energy production in the nutrient abundance milieu, but the role of AKT under metabolic stress is in dispute.

2022年9月19日 · We propose a minimal network model for the cellular response to glucose restriction, characterizing the glucose uptake and signaling of the AMPK, Akt, mTOR, and p53 pathways. We demonstrate that in the presence of sufficient growth factors and amino acids, cells may undergo proliferation, senescence, or apoptosis, depending on the extracellular ...

PI3K/Akt/mTOR信号通路是细胞内一条关键的信号传导通路，在调控细胞生长、代谢、增殖和存活等多种生理过程方面发挥着重要作用。 ... 在能量缺乏状态下，AMPK被激活，通过磷酸化TSC2或Raptor，间接抑制mTORC1的活性。AMPK通过抑制mTORC1，使细胞在能量不足时降低合成 ...

胰岛素信号转导通路通过 ULK1 激酶抑制自噬，这主要由 Akt 和 mTORC1 进行抑制，并由 AMPK 激活。 胰岛素促进肌肉和脂肪细胞中糖摄取是通过将 GLUT4 囊泡转运到质膜上。 GLUT4 的转运涉及到 PI3K/Akt 通路和 IR 介导的 CAP 的磷酸化，以及 CAP:CBL:CRKII 复合体的形成。 此外，胰岛素信号转导通过破坏 CREB/CBP/mTORC2 的结合抑制肝脏中的糖异生。 胰岛素信号转导通过调节 SREBP 转录因子诱导脂肪酸和胆固醇的合成。 胰岛素信号转导还可以通过激活 USF1 …