The diagnosis is primarily based on the structural findings seen on optical coherence tomography (OCT) imaging. OCT angiography may show void defects in deep capillary plexus and choriocapillaris. Patients with AMN report a sudden onset of one or more paracentral scotomas, decreased vision, and/or blurry vision.

Type 1 acute macular neuroretinopathy (AMN), also known as paracentral acute middle maculopathy (PAMM), is a novel form of AMN in which spectral-domain optical coherence tomography (SD-OCT) demonstrates a characteristic hyper-reflective band-like lesion at the level of the inner nuclear layer.

2019年4月1日 · Acute Macular Neuroretinopathy (AMN) DISCUSSION Etiology. Acute Macular Neuroretinopathy (AMN) is a rare condition that was first described in 1975 by Bos and Duetman as a brownish-red wedge shaped petalloid macular lesion around the fovea with corresponding paracentral scotomas [1].

2021年12月27日 · Meanwhile, OCT examination has important imaging value in differentiating AMN from PAMM and can help avoid missed diagnoses. We report one case of rare acute macular neuroretinopathy (AMN) in an elderly patient with hypertension and one case of common paracentral acute middle maculopathy (PAMM) in a patient with diabetes mellitus to illustrate ...

2024年6月13日 · ASHH occurs early in AMN then rapidly fades, and is followed by classic OCT features of AMN, including thinning of the ONL and disruption of the ellipsoid zone and interdigitation zone. 8,9 In fact, in our patient, ASHH was present one day after symptom onset, and had already begun to fade one week later, at which point disruption of the EZ and ...

OCT检查即可明确AMN视网膜病变位置和范围，是诊断AMN的可靠工具，同时为了解AMN的病理机制也提供了临床依据。 OCT表现为急性期（1-5天）外核层和外丛状层有明显的高反射灶；1周内高反射灶消失，外核层变薄，光感受器和视网膜色素上皮（RPE）黑色素变薄；在2-4周期间，光感受器细胞外节段损伤扩大，OCT主要表现为嵌合体带和椭圆体带缺失的扩大，对应于红外扫描图像暗区的扩大。 部分患者，1年后外核层持续变薄，即使椭圆体带恢复到正常后嵌合体带依旧 …

OCT-A may be a useful adjunct to the multimodal imaging of AMN/PAMM and may enhance visualization of the retinal microvasculature perfusion at a retinal layer level. The ability of OCT-A to differentiate laminar focal capillary defects that maybe undetected by FA is a potential significant advantage of OCT-A.

2019年2月13日 · Advances in imaging technologies have enabled optical coherence tomography (OCT) to be considered as a main biomarker during the course of AON through the assessment of axonal loss reflected by thinning of the retinal nerve fibre layer and the combined ganglion cell and inner plexiform layers (Petzold et al. 2017).

The en face OCT is a tomographic image processing technique, integrating data from entire A-scans to create a frontal retinal image of the desired area. Structural en face OCT imaging appears to be effective in delineating AMN lesions, using segmentation between the outer plexiform line and the ellipsoid line.

Acute macular neuroretinopathy acutely affects the outer nuclear and plexiform layers manifesting as OCT hyperreflectivity. The hallmark long-term changes are outer nuclear thinning on Fourier domain OCT and a fading dark lesion on IR reflectance imaging. These changes correspond to focal disruption …