Introduction: Trisomy 8 is one of the most common cytogenetic alterations in acute myeloid leukemia (AML), with a frequency between 10% and 15%. Areas covered: The authors summarize the latest research regarding biological, translational and clinical aspects of …

2023年11月2日 · Trisomy 8 is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). Trisomy 8 frequently occurs with additional aberrant or complex karyotypes; it can also occur as the sole cytogenetic abnormality.

Acute myeloid leukemia (AML) is a heterogeneous bone marrow malignancy, and patients with the cytogenetic t (8;21) abnormality represent a subset with specific clinical and biological characteristics [1].

2022年9月22日 · Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as “AML not otherwise specified” (AML-NOS) or “AML with myelodysplasia-related changes” (AML-MRC)

Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML …

2022年1月1日 · The translocation t (8;21) (q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). This subtype is strongly associated with French-American-British (FAB) subtype M2 (WHO).

2024年9月16日 · The t (8;21) (q22;q22) translocation is a common chromosomal abnormality in acute myeloid leukemia (AML). Although t (8;21) AML has a favorable prognosis, ~40% of the patients will...

Acute myeloid leukemia (AML) results from clonal expansion of transformed hematopoietic stem cells (HSCs) through the acquisition of genetic abnormalities including chromosomal rearrangements and multiple gene mutations whereby HSCs are conferred a proliferative and survival advantage and impaired hematopoietic differentiation.

Trisomy 8 is the most frequent cytogenetically gained aberration in AML. We compared 79 adult de novo AML with trisomy 8 as the sole cytogenetic abnormality (+8sole) to 511 normal karyotype AML patients (NK). +8sole patients were older (p=0.013), presented lower WBC counts (p=0.010), harbored more o …

The translocation t (8;21) is the single most common structural aberration in acute myeloid leukemia (AML). Excellent response rates and a better relapse-free survival were noted. We analyzed specific morphologic and cytochemical features including dysplasia and prognostic factors in forty-one patients with AML t (8;21).