2024年11月1日 · Studies demonstrate that inhibiting PFKP and silencing MALAT1 can hinder ALDH1 liver cancer stemness via the MALAT1/Wnt/β-catenin pathway. In lung cancer, targeting ALDH1 shows promise in mitigating chemoresistance and malignant proliferation, implicating the involvement of Wnt signaling pathways [165].

2022年10月27日 · ALDH1 can activate and transform various pathways (such as the USP28/MYC signaling pathway, ALDH1A1/HIF-1α/VEGF axis, wnt/β-catenin signaling pathway), as well as change the intracellular pH value to promote formation and maintenance, resulting in drug resistance in tumors.

In cancer stem cells, oncogenic pathways, such as WNT signaling and MUC1-C, upregulate ALDH1 transcription. ALDH1 is suggested to reduce oxidative stress, thus protecting the CSC population. Additionally, ALDH1 plays an important role in the oxidative-defense mechanism by catalyzing aldehydes.

2024年8月31日 · This review aims to fill in the gap between ALDH1 family members in relation to its cell signaling mechanisms, highlighting their potential as molecular targets to sensitize recurrent tumors and bring forward the future development concerning the …

2024年8月7日 · ALDH1A1, through the ZBTB7B-glycolysis pathway, instigates the excessive accumulation of lactic acid in the tumor microenvironment, culminating in the diminution of anti-tumor...

2024年11月1日 · Tumor microenvironmental factors such as hypoxia, cancer-associated fibroblasts (CAFs), and immune cells can modulate ALDH+ CSCs through pathways like CYP26A1. Elevated CYP26A1, driven by active WNT …

Here we review the functions and mechanisms of ALDH1A1, the key ALDH isozyme linked to SC populations and an important contributor to CSC function in cancers, and we outline its potential in future anticancer strategies. Keywords: aldehyde dehydrogenase, ALDH, ALDH1A1, cancer, stem …

Wnt pathway regulates ALDH1A1 through β-catenin/TCF-dependent transcription. MUC1-C induces ERK signaling and phosphorylates C/EBP β . The complex of MUC1-C and C/EBP β occupies the sequence upstream from the transcription initiation site of ALDH1, triggering ALDH1A1 expression.

2021年11月1日 · ALDH1A1 promoter can be activated by several molecular pathways: 1) Wnt pathway regulating ALDH1A1 through β-catenin and T-cell factor (TCF)-dependent transcription; 2) Transforming growth factor β (TGF-β) - downregulating ALDH1A1 in Smad4-dependent manner; 3) Mucin 1-C (MUC1-C) inducing extracellular-signal-regulated kinase (ERK) signalling ...

2024年5月27日 · In this review, we comprehensively analyze the tissue distribution, and functions of the ALDH1 family. Additionally, we review the involvement of the ALDH1 family in diseases, focusing on the underlying pathological mechanisms and briefly talk about the current status and development of ALDH1 family inhibitors.