负责人体内乙醛转化的主要是肝中的乙醛脱氢酶（aldh），它有两种 同功酶 ，分别分布于胞质溶胶（aldh1）与线粒体（aldh2）。 两者在催化速率上有很明显的差异，ALDH2对乙醛的 K_M 低于ALDH1，约后者的1/10，是主要负责乙醛转化的同工酶。

2021年12月26日 · 近日，复旦大学生物医学研究院/附属肿瘤医院柳素玲团队在Cancer Research杂志在线发表了题为ALDH1A1 activity in tumor-initiating cells remodels myeloid-derived suppressor to promote breast cancer progression 的研究性论文，揭示了ALDH1A1依赖其酶活性对乳腺癌免疫微环境的重塑和促肿瘤作用及其具体分子机制，帮助我们更好的阐明了BCSC标志物ALDH1A1对乳腺 肿瘤 发生发展的影响，为恶性乳腺癌的临床治疗提供了新的思路。

2022年10月27日 · ALDH1 is positively correlated with helicobacter pylori infection. When ALDH1 is overexpressed, it mainly restores the reduction of drug resistance caused by miR-625 overexpression. It is involved in the regulation of various genes and proteins in the process of GC occurrence and development .

2025年3月30日 · ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) is a Protein Coding gene. Diseases associated with ALDH1A1 include Alcohol Dependence and Anaerobic Meningitis. Among its related pathways are Oxidation by …

ALDH1A proteins play a key role in many biological processes, such as development, homeostasis, and tumorigenesis, through their enzymatic activity in retinoic acid (RA) signaling by converting retinal to RA (Figure 1). This ALDH-based step in the RA pathway is important because RA signaling controls cellular differentiation.

In a series of 577 breast carcinomas, expression of ALDH1 detected by immunostaining correlated with poor prognosis. These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts.

2024年12月30日 · The goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development.

2015年4月27日 · Recent studies have demonstrated that aldehyde dehydrogenase 1 (ALDH1) is a marker for CSCs in adult cancers. Although CSCs have been identified in some different types of pediatric solid tumors, there have been no studies regarding the efficacy of ALDH1 as a …

2016年3月8日 · The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH) genes, which encode enzymes critical for detoxification of endogenous and exogenous aldehyde substrates through NAD(P)+-dependent oxidation. ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker …

In addition, emerging evidence suggests that ALDH1 is not only a marker for stem cells, but may also play important functional roles related to self-protection, differentiation, and expansion. This comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1.