The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1.

蛋白磷酸酶通过使 Akt 或 PIP3 去磷酸化而充当 Akt 蛋白的负调节剂。 PI3K/Akt 信号通路对肿瘤细胞存活至关重要。存活因子可以通过激活 Akt1 以转录非依赖性方式抑制细胞凋亡，然后磷酸化和灭活细胞凋亡机制的组分。

AKT1（丝氨酸和苏氨酸激酶 AKT）也被称为蛋白激酶 B (PKB)。 AKT1 由胰岛素和多种生长和存活因子激活，在调节细胞生长和分裂和细胞凋亡抑制等多种过程中发挥着关键作用。 AKT 家族存在3个成员，AKT1 和 AKT2 分布较为广泛。 作为 PI3K/AKT/mTOR 信号通路中的关键蛋白，AKT1 可以阻止细胞凋亡从而促进细胞存活，被认为是许多类型癌症的主要因素。 AKT1 组织特异性低，在多种组织细胞中表达。 AKT1 主要定位于细胞质和细胞核中。 AKT1 被激活后会异位至细 …

2025年3月30日 · AKT1 (AKT Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with AKT1 include Proteus Syndrome and Cowden Syndrome 6. Among its related pathways are Prolactin Signaling and Regulation of activated PAK …

Akt1, a serine/threonine kinase, is a multi-functional protein implicated in regulation of cell growth, survival and proliferation. Though it has a role in G1/S progression, the manner by which Akt1 controls cell cycle and blends cell growth with proliferation is not well explored.

目前，akt丝氨酸/苏氨酸激酶家族共发现了三种高度同源的亚型，即akt1（pkbα）、akt2（pkbβ）和 akt3（pkbγ）。 AKT三种亚型分别由39个氨基酸铰链区隔开的N端pleckstrin同源 (PH) 域和大的中央激酶域以及C端调节域 (RD) 组成。

2025年2月19日 · In the AKT1–AtKC1 complex, interactions between the I-domain of AtKC1 and the C-linker of an adjacent AKT1 subunit induce a rotation of the C-linker toward the I-domain, compared to its position in the AKT1 structure (Figure 1 E). These interactions likely underpin AtKC1’s inhibition of AKT1 by stabilizing the closed conformation of the ...

akt1蛋白，也称为蛋白激酶b（pkb），是细胞信号传导途径中的一个关键分子，参与调控细胞生长、存活、代谢和分化等多种过程。 重组AKT1蛋白的研究为理解其在多种疾病中的角色提供了宝贵的见解，特别是在癌症和代谢性…

2025年3月9日 · CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and enhance chemo-resistance in ovarian cancer.

The AKT1 gene provides instructions for making a protein called AKT1 kinase. This protein is found in various cell types throughout the body, where it plays a critical role in many signaling pathways.