2025年3月30日 · AKR1C1 (Aldo-Keto Reductase Family 1 Member C1) is a Protein Coding gene. Diseases associated with AKR1C1 include Developmental Dysplasia Of The Hip 1 and Combined Oxidative Phosphorylation Deficiency 8 .

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.

该基因编码醛/酮还原酶超家族的一个成员，该家族由 40 多种已知的酶和蛋白质组成。 这些酶利用 NADH 和/或 NADPH 作为辅助因子，催化醛和酮转化为其相应的醇。 这些酶显示重叠但不同的底物特异性。 这种酶催化黄体酮与非活性形式 20-α-羟基-黄体酮的反应。 该基因与其他三个基因成员具有高度序列同一性，并与染色体 10p15-p14 上的这三个基因聚集在一起。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the aldo/keto reductase superfamily, which …

2024年10月30日 · Based on genomic analysis of ECC patient samples, here we report that aldo-keto reductase family 1 member C1 (AKR1C1) is highly expressed in human ECC tissues and closely associated with ECC...

AKR1C1 is a crucial regulator for cisplatin-resistance in HNSCC and also poor prognostic marker for patients. Targeting the AKR1C1-STAT axis may provide a new therapeutic strategy to treat patients who are refractory to cisplatin treatment.

2021年5月20日 · Aldo-keto reductase family 1 member C1 (AKR1C1) mainly catalyses the reduction of progesterone by utilising NADP + (oxidised form of nicotinamide adenine dinucleotide...

In the present study, we demonstrate that the aldo-keto reductase 1C1 (AKR1C1) is overexpressed in CRC cells upon acquisition of OXA resistance, evident in OXA-resistant CRC cell lines. We employed genetic silencing and pharmacological inhibition strategies to establish that suppression of AKR1C1 restores OXA sensitivity.

结果：两个铁死亡相关基因（AKR1C1和AKR1C3 ) 在 GSE22358、GSE9014 和 GSE8977 中显着表达。 AKR1C1的高表达与良好的预后相关。 TCGA- BRCA进一步证实了AKR1C1的表达和AKR1C1的预后价值。 共表达分析显示最丰富的 GO 术语和 KEGG 通路是 DNA 模板转录和范可尼贫血通路的终止。 随后，免疫学分析显示AKR1C1与各种免疫浸润细胞显着相关；其中，树突状细胞、中性粒细胞、巨噬细胞是浸润前三位的细胞。 此外，AKR1C1还与多种免疫刺激分子和趋 …

2022年1月5日 · Human aldo-keto reductase family 1C1 (AKR1C1) is an important enzyme involved in human hormone metabolism, which is mainly responsible for the metabolism of progesterone in the human body.

2022年1月5日 · Here we briefly reviewed the physiological and pathological functions of AKR1C1 and the relationship with the disease, and then summarized the development of AKR1C1 inhibitors, elucidated the interaction between inhibitors and AKR1C1 through molecular docking results and existing co-crystal structures.