2018年8月30日 · ADAMTS13 deficiency is the cause of TTP but also has a significant role in the pathophysiology, diagnosis, and prognosis of other TMAs and thrombotic disorders, such as …

ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing …

The ADAMTS13 gene provides instructions for making an enzyme that is involved in regulating blood clotting. After an injury, clots normally protect the body by sealing off damaged blood …

ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular …

2012年12月8日 · In the majority of TTP patients, ADAMTS13, the principal regulator of VWF size, is severely deficient. Today, 2 forms of severe ADAMTS13 deficiency are recognized. The …

In Panel A, in normal subjects, ADAMTS-13 (von Willebrand factor–cleaving metalloprotease) molecules attach to binding sites on endothelial cell surfaces and cleave unusually large …

ADAMTS13 is an enzyme that acts by cleaving prothrombotic von Willebrand factor (VWF) multimers from the vasculature in a highly regulated manner. In pathologic states such as …

ADAMTS13 evades canonical means of protease regulation because it is secreted as an active enzyme and has a long half‐life in circulation, suggesting that it is not inhibited by natural …

2025年2月8日 · ADAMTS13 inhibits H2O2-induced human venous endothelial cell injury to attenuate deep-vein thrombosis by blocking the p38/ERK signaling pathway. ADAMTS13 …

2025年3月30日 · ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13) is a Protein Coding gene. Diseases associated with ADAMTS13 include Thrombotic …