A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of …

A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface proteins, …

AMAM17是一种参与多种蛋白质胞外域脱落的跨膜金属蛋白酶，具有黏附和蛋白水解特性，它可以使肿瘤坏死因子-α（TNF-α）前体转化为可溶性的TNF-α。 除了剪切TNF-α，该蛋白酶还在许 …

2023年1月12日 · 可溶性TNF-α通过蛋白水解酶ADAM17，也称为TNF-a转换酶（TACE），从跨膜TNF-α（tmTNF-α）裂解，该酶可通过激活TNF-α来协调免疫和炎症反应。 鉴于ADAM17 …

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

In this review, we summarize data on the physiological role of ADAM17 in health and disease. Here we provide an overview of ADAM17 substrates, mouse models of ADAM17-deficiencies …

2011年8月1日 · A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface …

2019年6月1日 · The topic of this review article is the metalloprotease ADAM17, one of the best-studied shedding proteases. We will summarize current knowledge about the basic biology of …

2024年3月11日 · ADAM17是一种重要的蛋白酶，属于金属蛋白酶超家族，也被称为TNF-α转化酶，非常关键的参与细胞信号传导的调控。 ADAM17的全称为重组蛋白酶活性域蛋白，其特点 …

2022年11月17日 · ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins …