ABCC1 - Wikipedia
ABCC1 plays a role in the multidrug resistance of cancerous tumor cells due to its ability to transport many chemotherapeutic drugs out of the cells. The ABCC1 transporter protein is …
ABCC1 Gene - GeneCards | MRP1 Protein | MRP1 Antibody
2025年3月28日 · ABCC1 (ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)) is a Protein Coding gene. Diseases associated with ABCC1 include Deafness, Autosomal …
ATP 结合盒亚家族 C 成员 1（ABCC1）基因 | MCE
由该基因编码的蛋白质是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD …
Cell Chem Biol重大发现！ABCC1竟成癌细胞抵抗PROTAC治疗的关 …
2024年12月24日 · 这项研究成功揭示了ABCC1作为关键外排泵，持续限制多种癌细胞对PROTAC的敏感性，为理解PROTAC在癌细胞中的转运机制和耐药问题提供了重要依据。 尽 …
ABCC1 and glutathione metabolism limit the efficacy of BCL-2
2023年9月19日 · ATP-binding cassette (ABC) transporters mediate chemotherapy resistance but their role in modulating the activity of targeted small-molecule inhibitors is unclear. Using …
Multidrug Resistance Protein 1 (MRP1, ABCC1), a …
The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …
Structures of ATP-binding cassette transporter ABCC1 reveal the ...
2025年1月14日 · ABCC1 (also known as multidrug-resistant protein 1 [MRP1]) actively pumps a variety of anti-cancer drugs out of the malignant cells using the energy from ATP. 31 In …
Immunity: ABCC1在感染和肿瘤免疫靶向研究中的新突破 | Cell …
2025年1月10日 · 近期在人类和小鼠细胞中的研究已发现ATP结合盒（ABC）C亚家族成员1（ABCC1）是一个直接的ATP依赖性cGAMP外排泵。 这些研究还表明，细胞内源性 …
Multidrug resistance-associated protein 1 (MRP1/ABCC1) …
Multidrug resistance-associated protein 1 (MRP1/ABCC1) is the first identified member of ABCC subfamily which belongs to ATP-binding cassette (ABC) transporter superfamily. It is …
ABCC1 transporter exports the immunostimulatory cyclic …
2022年10月11日 · We demonstrate that ABCC1 deficiency exacerbated cGAS-dependent autoimmunity in the Trex1−/− mouse model of Aicardi-Goutières syndrome. Thus, ABCC1 …