ABCB4 - Wikipedia
The ATP-binding cassette 4 (ABCB4) gene encodes multidrug resistance protein 3. [5] [6] [7] ABCB4 is associated with progressive familial intrahepatic cholestasis type 3 and intrahepatic …
ABCB4 Gene - GeneCards | MDR3 Protein | MDR3 Antibody
2025年3月28日 · ABCB4 (ATP Binding Cassette Subfamily B Member 4) is a Protein Coding gene. Diseases associated with ABCB4 include Cholestasis, Progressive Familial Intrahepatic, …
ABCB4基因的研究进展.doc 6页 VIP - 原创力文档
2017年7月10日 · ABCB4基因编码的蛋白是一种磷脂酰胆碱易位酶，可以将磷脂酰胆碱转移人胆汁 ，乳化胆汁中的胆盐，保护胆管上皮免受胆盐损伤[1] 。 ABCB4基因的突变可能会导致胆管损 …
汤善宏教授团队：胆汁酸代谢过程中转运蛋白基因突变机制及临床 …
2023年3月11日 · MDR3由ABCB4编码，主要在肝细胞的小管膜上表达并充当磷脂转运蛋白。 它的功能主要是将肝细胞内的磷脂酰胆碱转运到胆管腔，与胆汁酸混合后降低对胆管细胞毒性作用 …
ATP 结合盒亚家族 B 成员 4（ABCB4）基因 | MCE
由该基因编码的膜相关蛋白是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP …
ABCB4 disease: Many faces of one gene deficiency - PubMed
ATP-binding cassette (ABC) subfamily B member 4 (ABCB4), also known as multidrug resistance protein 3 (MDR3), encoded by ABCB4, is involved in biliary phospholipid secretion, protecting …
ABCB4 gene - MedlinePlus
The ABCB4 gene (also known as MDR3) provides instructions for making a protein that helps move certain fats called phospholipids across the membranes of liver cells. The protein …
【消化疾病研究】新型ABCB4基因突变所致的进行性家族性肝内胆 …
2024年7月23日 · PFIC3由ATP结合盒转运蛋白B4（ATP binding cassette subfamily B member 4，ABCB4）基因突变导致，婴儿多以黄疸、瘙痒、白陶土便为首发症状，常在儿童期就进展 …
ABCB4突变基因型与表型的相关性 - lcgdbzz.org
Abstract: ABCB4-related disease is the syndrome of bile secretion disorder caused by gene mutations and can cause bile duct injury, portal hypertension, and liver cirrhosis in clinical …
Genetic Analysis of ABCB4 Mutations and Variants Related to the ...
Clinical studies have revealed that the ABCB4 gene encodes the phospholipid transporter on the canalicular membrane of hepatocytes, and its mutations and variants are the genetic basis of …