2024年6月1日 · A MSNs-ABC@polydopamine-OVA (MSNs-ABC@PDA-OVA) nanovaccine as an example, employed polydopamine (PDA)-modified MSNs as a porous backbone, encapsulating ABC and conjugating thiolate ovalbumin via Michael addition reaction [52].

2021年3月21日 · 单次注射msns-abc@pda-ova后结合单次光热治疗即可成功根除黑色素瘤，治愈率达75%，并且可以产生强大的免疫记忆以抑制肿瘤复发和肺转移。 这一研究为癌症治疗提供了一种简单而有前景的新型协同策略。

2022年7月1日 · The MSNs-ABC@PDA-OVA nanovaccine achieves rapid antigen release and endosome escape, enhances dendritic cells (DCs) activation and maturation, facilitates migration to tumor-draining lymph nodes, and induces robust antitumor immune responses when exposed to an 808 nm for 5 min with a 2.5 W/cm 2 NIR laser.

近日， 中国医学科学院生物医学工程研究所 张琳华研究员、朱敦皖研究员和南开大学 孔德领 教授在《Advanced Functional Material》上发表了题为“Robust Nanovaccine Based on Polydopamine-Coated Mesoporous Silica Nanoparticles for Effective Photothermal-Immunotherapy Against Melanoma”的文章，该 ...

2021年11月24日 · The MSNs-ABC@PDA-OVA nano-vaccine showed excellent photothermal properties and effectively ablated the primary tumor. Under laser irradiation, the MSNs-ABC@PDA-OVA nano-vaccine also achieved rapid antigen release and endosomal escape, enhanced the activation and maturation of dendritic cells, and promoted their migration to tumor-draining lymph ...

2021年3月21日 · 中国医学科学院生物医学工程研究所张琳华研究员、朱敦皖研究员和南开大学孔德领教授设计了一种以介孔二氧化硅纳米颗粒(msns)为载体的纳米平台，该平台集成了光热试剂聚多巴胺(pda)、模型抗原卵清蛋白(ova)和抗原释放启动子碳酸氢铵(abc)，可用于对黑色素瘤 ...

In this review, we introduce nanoparticle (NP)-based combination cancer therapies that use organic and inorganic NPs. Liposomes, polymers, and exosomes can be prepared with amphiphilic properties, high physical stability, and low immune response to treat cancers in a multimodal way.

2023年5月1日 · The densely coated polydopamine/ammonium bicarbonate (PDA/ABC) and hyaluronic acid (HA) layers on the surface of the nanoplatform enhanced the cancer-targeting capacity and induced the acidic TME-triggered in situ “bomb-like” release of Art.

2021年2月24日 · Under laser irradiation, the MSNs‐ABC@PDA‐OVA nanovaccine realizes rapid antigen release and endosome escape, enhances dendritic cells activation and maturation, facilitates migration to tumor ...

Under laser irradiation, the MSNs‐ABC@PDA‐OVA nanovaccine realizes rapid antigen release and endosome escape, enhances dendritic cells activation and maturation, facilitates migration to tumor‐draining lymph nodes, and induces robust antitumor immune responses.