Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene [5][6][7] and is involved in clathrin mediated endocytosis.

AAK1靶点的成药性连接蛋白相关激酶1 (AAK1)是治疗神经性疼痛的可行靶点，这在小鼠敲除表型中首次得到证实。 AAK1为 丝氨酸 /苏氨酸激酶的Arkl/Prkl家族的成员，且已被鉴定为PC12细胞中神经调节蛋白- l/ErbB4信号传导的抑制剂。

2025年3月28日 · AAK1 (AP2 Associated Kinase 1) is a Protein Coding gene. Diseases associated with AAK1 include Hepatitis C Virus and Hepatitis C. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis.

Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the adapter complex-2 (AP-2) protein.

AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively. Title: AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.

外源性转染AAK1-3xFLAG及FMRP-MYC质粒，利用抗FLAG琼脂糖凝胶富集AAK1-3xFLAG后，可以检测到FMRP-MYC的表达；利用内源性抗体进行CoIP，发现富集AAK1可以检测到FMRP的表达。

2023年2月15日 · Adaptor-Associated Kinase 1 (AAK1), a Ser/Thr protein kinase, responsible for regulating clathrin-mediated endocytosis, is ubiquitous in the central nervous system (CNS). AAK1 plays an important role in neuropathic pain and a variety of other human diseases, including viral invasion, Alzheimer's dis …

2024年3月20日 · TIM-098a could inhibit AAK1 activity in transfected cultured cells (IC 50 = 0.87 µM), indicating cell-membrane permeability of the compound. Overexpression of AAK1 in HeLa cells significantly...

2025年1月6日 · 本文将详细介绍AAK1基因的功能、作用机制、信号通路及其与疾病的关系。 AAK1基因，也称为AP2 associated kinase 1，位于人类染色体2p13.3，是一个重要的蛋白质编码基因，参与多种细胞内信号传导过程，并与多种疾病的发生发展密切相关。

2025年2月8日 · Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis