Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. [5] A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases .

In Islam, al-A'raf (Arabic: الأعراف) is a separator realm or borderland between Jannah (heaven) and Jahannam (hell), [2] inhabited by those who are evenly balanced in their sins and virtues, they are not entirely evil nor are they entirely good. This place may be described as a kind of benevolent purgatory with privation but without suffering.

Read and listen to Surah Al-A'raf. The Surah was revealed in Mecca, ordered 7 in the Quran. The Surah title means "The Heights" in English and consist...

2025年3月30日 · ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include Pallister-Killian Syndrome and Lymphatic System Disease. Among its related pathways are Prolactin Signaling and Signaling downstream of …

In this review, we discuss the regulation of A-Raf protein expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf inhibitors. We also describe the scaffold functions of A-Raf and summarize the unexpected complexity of …

A-Raf 原癌基因，丝氨酸/苏氨酸激酶： 该原癌基因属于 Ser/Thr 蛋白激酶家族的 Raf 亚家族，可能参与细胞的生长发育。 已发现该基因编码不同亚型的可变剪接转录本变体。

2025年1月27日 · RAS-RAF-MAPK通路是多种膜受体传导的生长信号跨膜传递的交汇点，参与细胞的增殖、分化、凋亡、炎症反应等多种生理过程。 处于持续激活状态下的RAS-RAF-MAPK通路通常会造成细胞增殖或分化异常，因此，该通路中各成员蛋白的突变和异常表达与多种恶性肿瘤的发生发展密切相关。 作为该通路的核心传导因子，RAF蛋白有三个异构体，分别为ARAF …

The Royal Air Force (RAF) is the air and space force of the United Kingdom, British Overseas Territories and Crown Dependencies. [7] It was formed towards the end of the First World War on 1 April 1918, on the merger of the Royal Flying Corps …

A-Raf binds and inhibits the proapoptotic kinase mammalian sterile 20-like kinase (MST2). A-Raf binds to MST2 constitutively, and seems to promote the survival of cancer cells (Rauch et al. 2010). By contrast, Raf-1 binding to MST2 is induced by stress and relieved by mitogens, while B-Raf does not detectably bind MST2 (O’Neill et al. 2004 ...

A-Raf is one of the members of the Raf family, possess a Ras-binding domain (RBD) in their N-terminal regulatory region and can function as effectors of active GTP-bound. A-Raf can be activated by the human oncogene RAS family, downstream from which exerts both kinase-dependent and kinase-independent, tumor-promoting functions.