2023年6月28日 · Our findings expand the repertoire of targetable cysteines within protein kinases, provide insight into unique binding modes identified from crystal structures and deliver isoform-specific hits with promising profiles as starting points for the development of highly potent and selective covalent inhibitors.

2023年9月20日 · PDBe › 8pm3. X-ray diffraction. 2Å resolution. Crystal structure of MAP2K6 with a covalent compound GCL94. Released: 20 Sep 2023. DOI: 10.2210/pdb8pm3/pdb. Source organism: Homo sapiens. Entry authors: Wang GQ, Seidler N, Roehm S, Gehringer M, Knapp S, Structural Genomics Consortium (SGC)

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Molecular Components in 8PM3; Label Count Molecule; Protein (1 molecule) A. 1: Dual Specificity Mitogen-activated Protein Kinase Kinase 6. Chemical and Non-standard biopolymers (1 molecule) 1. 1 ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide (Link to PubChem not yet available)

2023年6月28日 · Structural Genomics Consortium. Registered charity 04714553 (England and Wales). Registered company limited by guarantee 1097737 (England and Wales).

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PDB Entry - 8PM3 (Status - Released) Summary information: Title: Crystal structure of MAP2K6 with a covalent compound GCL94. PDB DOI: https://doi.org/10.2210/pdb8pm3/pdb. Entry authors: Wang, G.Q., Seidler, N., Roehm, S., Gehringer, M., Knapp, S., Structural Genomics Consortium (SGC) Initial deposition on: 28 June 2023. Initial release on: 20 ...

8PM3 Crystal structure of MAP2K6 with a covalent compound GCL94. Summary for 8PM3. Entry DOI: 10.2210/pdb8pm3/pdb: Descriptor: Dual specificity mitogen-activated protein kinase kinase 6, ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide (3 entities in total) Functional Keywords:

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Authors: G.Q.Wang,N.Seidler,S.Roehm,M.Gehringer,S.Knapp,Structural Genomics Consortium (Sgc) Key ref: G.Q.Wang et al. Crystal structure of map2k6 with a covalent ...