2015年1月18日 · 5xFAD mice develop motor impairments, beginning at about 9 months of age (O’Leary et al., 2018; O’Leary et al., 2018). On the Rotarod, transgenic mice fall off more …

2025年1月30日 · 5xFAD mice showed signs of reduced anxiety in two behavioral tests frequently used to evaluate this phenotype. Transgenic mice spent more time in the center of an open …

2018年4月6日 · There was a modest decrease in PBS-soluble Aβ in hippocampus in CV-KO-5XFAD compared with KO-5XFAD mice. The neurodegeneration-associated microglial …

2020年11月27日 · These data indicate that Aβ is the cause of neuronal degeneration and death in 5XFAD mice, rather than an artifact resulting from mutant APP and PS1 overexpression. Our …

2018年4月6日 · Humanized TREM2 mice were crossed with 5XFAD mice to obtain 5XFAD expressing the R47H variant (R47H + mTrem2 −/− 5XFAD, or R47H-KO-5XFAD) or the …

2018年5月4日 · The number of plaque-associated microglia was reduced in TREM2-BAC X 5xFAD (5xFAD/TREM2) mice compared with 5xFAD mice at 7 months of age. Microglial …

2024年10月11日 · In 5xFAD mice, this antibody reportedly makes a good ARIA model (Mar 2024 conference news). Indeed, as per mouse MRI, the unmodified 3D6 antibody provoked ARIA …

2024年12月7日 · In 5xFAD mice, a similar analysis revealed substantial overlap in plaque-associated genes between mouse and human samples. Swarup said the findings bolster …

2024年9月19日 · First author Claire Butler and colleagues wanted to know how this variant would affect amyloid plaques, so they initially crossed the V1613M strain to 5xFAD mice. The …

2024年3月21日 · Neurons from 5xFAD TREM1 KOs seemed healthier, too, with neurites near cortical plaques being preserved. In mitochondria isolated from synaptosome fractions of APP …