Immunohistochemical Detection of 5T4 in Renal Cell Carcinoma
2023年2月6日 · These data identify mAbs suitable for detecting 5T4 in formalin-fixed, paraffin-embedded tissues and demonstrate both interpatient and histologic subtype heterogeneity. …
5T4 oncofoetal antigen: an attractive target for immune …
The 5T4 oncofoetal antigen was identified by searching for surface molecules shared between human trophoblast and cancer cells with the rationale that they may function to allow survival …
5T4 (TPBG) 药靶筛选模型-技术文章-南京科佰生物 - cobioer.com
2024年11月28日 · 癌胎抗原5T4，又称滋养层糖蛋白(trophoblast glycoprotein )TPBG，也称为Wnt 激活抑制因子 1（WAIF1）。是一种分子量为72kd, 由TPBG基因编码的N端高度糖基化的I型 …
Detecting expression of 5T4 in CTCs and tumor samples from …
In this present study, we have performed bioinformatics analysis to demonstrate 5T4 mRNA expression in both adenocarcinoma and squamous cell carcinoma of lung. Using 5T4-specific …
Immunohistological distribution of 5T4 antigen in normal and …
A trophoblast cell surface antigen has been characterised by a monoclonal antibody (mAb) 5T4, raised following immunisation with solubilised wheat germ agglutinin binding glycoproteins …
Expression of the 5T4 oncofoetal antigen in renal cell ... - Nature
2005年9月13日 · The 5T4 oncofoetal antigen is a heavily glycosylated cell surface protein found on human placental trophoblast and on diverse types of human cancer but is not expressed at …
889 DuoBody®-CD3x5T4 在体外和离体诱导有效的 T 细胞活化和 …
结果 IHC 分析证实了 5T4 在 HNSCC 口腔活检组织中的表达，包括来自原发性肿瘤、复发性肿瘤的标本和淋巴结转移。 患者来源的 HNSCC 细胞系 (n=22) 在质膜上表现出 5T4 表达，每个细 …
The Bispecific Tumor Antigen-Conditional 4–1BB x 5T4 Agonist, …
2023年1月3日 · ALG.APV-527 is uniquely designed for 5T4-conditional 4–1BB–mediated antitumor activity with potential to minimize systemic immune activation and hepatotoxicity …
5T4 oncofoetal antigen: an attractive target for immune
2016年10月18日 · The 5T4 oncofoetal antigen was identified by searching for surface molecules shared between human trophoblast and cancer cells with the rationale that they may function …
Immunotherapies Targeting a Tumor-Associated Antigen 5T4 …
2020年9月25日 · The use of 5T4 antibody-drug conjugates selectively targeting 5T4-positive tumor-initiating cells in combination with chemotherapy has shown considerable promise in …