4T1 is a 6-thioguanine resistant cell line selected from the 410.4 tumor without mutagen treatment. When injected into BALB/c mice, 4T1 spontaneously produces highly metastatic tumors that can metastasize to the lung, liver, lymph nodes and brain while the primary tumor is …

Surgically-Induced Multi-organ Metastasis in an Orthotopic Syngeneic Imageable Model of 4T1 Murine Breast Cancer.

The murine mammary cancer cell line 4T1 is one of the most often used model systems for breast cancer and in particular TNBC. Here, we could confirm that 4T1 indeed resembles metastatic TNBC at the transcriptional level with respect to key markers Esr1, Erbb2, and Pgr.

4T1细胞是从410.4瘤株中未经诱变筛得的6-硫鸟嘌噙抗性细胞株。 当4T1细胞注射到BALB/c小鼠中时，4T1细胞会自发产生高转移肿瘤，可转移到肺、肝、淋巴结和大脑，同时在注射部位形成始发灶，诱导转移时不需要摘除始发灶。 4T1细胞在BALB/c小鼠中的生长与转移特性与人体中的乳腺癌十分相近，这种肿瘤是人Ⅵ期乳腺癌的动物模型。 4T1细胞诱导的肿瘤在手术后及未手术情况 …

Jul 23, 2020 · The 4T1 murine mammary cancer cell line is one of the most widely used breast cancer models. Here, we present an integrated map of the genome, transcriptome, and immunome of 4T1. Results: We found Trp53 (Tp53) and Pik3g to be mutated.

4T1 cells are 6-thioguanine (6-TG)–resistant murine MBC cells derived from a lung metastasis of the 410.4 cell line, itself a fourth transplant generation of a metastatic nodule of the syngeneic 410 tumor cell line in BALB/c mice (28, 29). 4T1 cells generate primary tumors and spontaneously metastasize to multiple distant sites following ...

4T1 is a breast tumour cell line originating from a mammary tumour that spontaneously arose in mouse BALB/c strain. These highly invasive and tumorigenic cells closely mimic human breast cancer's behaviour in terms of growth and metastatic spread. Specifically, the 4T1 tumour model investigates triple-negative breast cancer (TNBC).

Aug 9, 2008 · The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modified to facilitate analysis of tumor growth and metastasis and evaluation of gene function in vivo.

The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models (CLS=300300). Doubling time: 12.6 hours (ATCC=CRL-2539).

Sep 4, 2024 · To investigate how E-cadherin regulates metastasis, we examined the highly metastatic, E-cadherin-positive murine 4T1 breast cancer model, together with the less metastatic, 4T1-related cell lines 4T07, 168FARN and 67NR.