4-硝基喹啉 N-氧化物（4-Nitroquinoline N-oxide，4-NQO）是一种水溶性喹啉衍生物，已被用作模型化合物以研究其致癌作用，还可用于有机合成。 4-硝基喹啉 N-氧化物能够通过氧化应激损伤和抑制DNA合成等机制诱导鳞状细胞癌的产生，且4-硝基喹啉 N-氧化物诱导肿瘤的产生具有组织特异性，口服主要诱导口腔及上消化道系统肿瘤的形成，皮下注射主要诱导肺癌的形成。 产品性质. CAS号（CAS NO.） 运输和保存方法. 干冰运输。 -20℃避光防潮密闭干燥保存，2年有效。 …

Nitrochin (4-NQO) 是一种化学致癌物质。 Nitrochin 在食管细胞中诱导制瘤素-M (OSM) 产生。 Nitrochin 诱导 DNA 损伤，并通过 p53 依赖性线粒体信号通路诱导凋亡 (apoptosis)。 * Please select Quantity before adding items. Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells.

4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound used in the assessment of the efficacy of diets, drugs, and procedures in the prevention and treatment of cancer in animal models.

4-Nitroquinoline N -oxide is a quinoline derivative widely used in chemical research and development. [1] 4-Nitroquinoline N -oxide has been used as a model compound to study its carcinogenic effects. [2] [3] Skin and lung tumor initiator under experimental conditions. Choose from one of the most recent versions: Don't see the Right Version?

4-硝基喹啉 N -氧化物是一种广泛应用于化学研究和开发的喹啉衍生物。 [1] 4-硝基喹啉 N -氧化物已被用作模型化合物以研究其致癌作用。 [2] [3] 在试验条件下可诱发皮肤和肺肿瘤。 没有发现合适的版本？ 如果您需要特殊版本，可通过批号或批次号查找具体证书。 已有该产品？ 在文件库中查找您最近购买产品的文档。 Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia …

4-Nitroquinoline-1-Oxide is a quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly to DNA and disrupting replication or through the generation of reactive oxygen species (ROS). 4-NQO is also metabolized to form other mutagenic compounds, such as 8-hydrox...

The 4NQO carcinogen model has the advantage that it can be used with transgenic mice with genetic modification in specific tissue types to investigate their role in driving cancer progression. Herein, we describe the basic approach for administering 4NQO to mice to induce OSCC and methods for assessing the tissue and disease progression.

使用化学致癌物 4-硝基喹啉-1-氧化物 (4NQO) 的重要大鼠模型已被描述用于口腔癌发生过程的研究。 该模型复制了在口腔癌患者中看到的逐渐进展。 然而，由于其高毒性，其在基础研究中的应用具有挑战性。 在这里，我们提出了一种基于较低剂量 4NQO 浓度以及增加供水和高热量饮食的安全有效的修改方案，以减少口腔癌变过程中对动物造成的损害。 将 22 只雄性 Wistar 大鼠暴露于 4NQO，每周进行一次临床评估，并在 12 周和 20 周时实施安乐死以进行组织病理学分析。 …

2021年1月1日 · The importance of the 4NQO mouse model is that it mimics the stepwise progression observed in OSCC patients. The 4NQO carcinogen model has the advantage that it can be used with transgenic mice with genetic modification in specific tissue types to investigate their role in driving cancer progression.

The 4NQO molecule forms DNA adducts, causes substitutions of adenosine for guanosine, and evokes intracellular oxidative stress, resulting in genetic mutations and DNA strand breaks.