2023年5月5日 · 在2019年Nature上发表的一项研究发现，产热脂肪细胞中特异性表达一种CLSTN3β蛋白，定位于内质网膜，通过促进S100b（棕色脂肪细胞分泌生长因子）蛋白的表 …

2024年4月23日 · How this LD heterogeneity arises is an important yet unresolved cell biological problem. Here, we show that an unconventional integral membrane segment (iMS) targets the …

Four-dimensional live cell imaging of LD consumption in 3T3-L1 adipocytes. All imaged LDs decrease their size significantly within 2 h after stimulation of lipolysis by forskolin. In addition, …

2013年3月12日 · Because lipid exchange is a hallmark of Fsp27-mediated LD growth, we measured the neutral lipid exchange rate in 3T3-L1 adipocytes in which Plin1 was knocked …

2024年11月2日 · CLSTN3B ablation results in reduced LD surface phospholipid density, increased turnover of LD-surface proteins, and impaired LD functions. Our results establish …

This work demonstrates that 3T3-L1 cells represent an excellent model to study the process of lipid accumulation in cytoplasm. The shape of the detected LDs resulted almost perfectly …

2017年6月2日 · Unlike the prototypical LD protein PLIN1, LDAH was readily detectable in undifferentiated 3T3-L1 cells, which is in line with the finding of ER-associated LDAH in the …

3t3-l1细胞系不仅可以稳定传代而且具有很好的向脂肪细胞分化的特异性，因此成为国际上公认的研究脂肪代谢的细胞模型，对脂肪细胞的增殖与分化的研究具有重大科研价值。

3T3-L1细胞是一种小鼠胚胎成纤维细胞系，最早于1974年由Green和Kehinde等人从小鼠胚胎中分离得到。 这种细胞系由于其能够在体外分化为类脂肪细胞，被广泛应用于肥胖和糖尿病等代 …

Adipocytes derived from 3T3-L1 cells are a gold standard for analyses of adipogenesis processes and the metabolism of fat cells. A widely used histological and immunohistochemical staining …