2022年8月， 特应性皮炎 靶向药物 Nemolizumab （商品名Mitchga）于日本正式上市。 Mitchga是全球首款通过竞争性抑制 IL-31RA 来抑制瘙痒的治疗性抗体，可有效改善特异性皮炎患者的生活质量。 细胞因子 是控制细胞通讯的关键。 白细胞介素31（IL-31）于2004年被发现是IL-6家族细胞因子的关键成员。 现有研究表明，IL-31对皮肤、气道、肺和肠道等的先天免疫和适应性免疫都很重要。 IL-31的表达增强与许多疾病相关，包括瘙痒性疾病（如特应性皮炎）、过敏和炎症性肠 …

ELISA Data: Immobilized Human IL-31 RA, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 6.5ng/ml determined by ELISA . Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

2024年11月29日 · Nemolizumab（商品名Mitchga）是全球首款通过竞争性抑制IL-31RA来抑制瘙痒的治疗性抗体。 IL-31的受体和信号传导 与那些疾病有关？ 1、特应性皮炎（AD）：IL-31是一种促瘙痒的细胞因子，与IL-33共同构成炎症轴IL-31/IL-33，参与特应性皮炎的发病机制。 IL-31和IL-33的相互作用可以激活细胞外信号调节激酶，并诱导促炎细胞因子IL-6和其他皮炎相关趋化因子的过表达，加剧炎症反应。 2、银屑病（Psoriasis）：研究发现，受银屑病影响患者的IL-31水平 …

Le 31e régiment d'artillerie (31e RA) est une unité d'artillerie de l'armée française, créée en 1873. .... Le 31e régiment d'artillerie est formé au Mans le 28 septembre 1873 lors de la réorganisation des corps d'artillerie français, avec : Le régiment fait partie de la 4e brigade d'artillerie.

IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M …

2025年3月30日 · IL31RA (Interleukin 31 Receptor A) is a Protein Coding gene. Diseases associated with IL31RA include Amyloidosis, Primary Localized Cutaneous, 2 and Primary Cutaneous Amyloidosis. Among its related pathways are Cytokine Signaling in Immune system and Interleukin-6 family signaling.

RayBio® Human IL-31 RA ELISA Kit for Serum, Plasma, and Cell Culture Supernatants. Lead time: Typically ships within 1-2 business days. No Friday shipments. This ELISA antibody pair detects Human IL-31 RA. Other species not determined. Need more sensitivity? Check out the new NexaTag™ kit for this target. Still not enough?

Detects mouse IL-31 RA in direct ELISAs and Western blots. Polyclonal Goat IgG. Antigen Affinity-purified. Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Detects human IL-31 RA in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross‑reactivity with recombinant mouse. IL‑31 RA is observed. Polyclonal Goat IgG. Antigen Affinity-purified. Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.