2-Oxoglutarate-dependent dioxygenases in cancer - Nature
2020年10月21日 · 2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological processes, including regulation of...
科普 | 抗衰的重要物质——AKG - 科普知识
2024年8月16日 · α-酮戊二酸 (A KG)也称为2-氧戊二酸 (2-OG)，是能量代谢和氨基酸合成过程中的重要分子，既参与脂肪酸、氨基酸和葡萄糖的氧化，同时在呼吸作用中作为三羧酸 (TCA)循环 …
Frontiers | Identification of Disease-Related 2-Oxoglutarate/Fe (II ...
2021年7月15日 · In this study, we developed OGFE_RAAC, a prediction model to identify whether a protein is a 2OG oxygenase. To improve the performance of OGFE_RAAC, 673 amino acid …
Catalytic Mechanisms of Fe (II)- and 2-Oxoglutarate-dependent ...
Here, four of the major types of Fe (II)/2OG-dependent reactions are detailed: hydroxylation, halogenation, ring formation, and desaturation. In addition, an atypical epimerization reaction …
α-酮戊二酸二甲酯 (DM-2KG)上调缺氧诱导因子-1α (HIF-1α)诱发高 …
结论: DM-2KG 可以通过抑制 PHD2 功能，上调 HIF-1α 蛋白水平，从而抑制乳腺癌 细胞增殖，并诱发产生一表达 CD44-high 和 Ki67-low、具静止期和干细胞样特 点及高致瘤性的癌细胞亚群 …
Amazing Diversity in Biochemical Roles of Fe (II)/2 …
2018年7月1日 · 2OG-dependent oxygenases are increasingly associated with genetic disorders and cancers, stimulating intense efforts to develop specific therapeutic agents directed at …
Integrative view of 2-oxoglutarate/Fe (II)-dependent oxygenase ...
2017年2月1日 · Our observations suggest relatively low evolutionary pressure on the bacterial 2OG oxygenases and a straightforward electron transfer pathway catalyzed by the two-domain …
用于调制α-酮戊二酸(2OG)依赖型加氧酶并作为其功能替代的化合 …
癌症治疗的基石，包括后来表观遗传治疗的成功，均采用了有效合理的药物组合。 核心在于将表观遗传活性药物 (包括我们的2og功能替代共基质)与其他疗法相结合，并进行优化。 有鉴于 …
Genome-wide characterization of 2-oxoglutarate and Fe(II) …
2021年2月18日 · 2-Oxoglutarate-dependent dioxygenases (2OGDs) are soluble, nonheme iron-containing enzymes and constitute the second-largest enzyme family in plants; these enzymes …
细菌中2-氧戊二酸/ Fe（II）依赖性加氧酶多样性和功能的综合观 …
Our observations suggest relatively low evolutionary pressure on the bacterial 2OG oxygenases and a straightforward electron transfer pathway catalyzed by the two-domain 2OG oxygenase. …