如何读懂染色体显带及命名？ - 知乎专栏
人类细胞分裂中期染色体一般具有以下结构：染色单体、长臂（q）、短臂 (p)、主缢痕、次缢痕、随体（图1）。 人体的24种染色体长短不一，因此，根据上述结构分为三种类型：1）中央着 …
IF:69.504｜CCNE1扩增与PKMYT1激酶抑制存在合成致死 - 知乎
染色体19q12上的ccne1位点扩增在多种肿瘤类型中普遍存在。 作者使用 CRISPR-Cas9 基因编辑技术设计了一种新药——RP-6306，该药物对于一些难以治疗癌症中的扩增细胞的酶显示出阻 …
Comprehensive analysis of 19q12 amplicon in human gastric …
2006年3月31日 · Amplification at 19q12 has been observed in multiple tumor types, while cyclin E1 (CCNE1) has been considered to be the key oncogene within this amplicon. We have …
Characterization of the 19q12 amplification including CCNE1 …
The combination of 19q12 amplification with Cyclin E1 and URI protein expression may help to select patients more likely to benefit from CDK2 targeted therapies. The novel 19q12 ISH …
Characterization of the 19q12 amplification including CCNE1 and …
Amplification of 19q12 was found in 49 (36.6%) of the carcinomas and significantly associated with advanced FIGO stage and older patient age. 19q12 amplification occurred in all histologic …
Comprehensive analysis of 19q12 amplicon in human gastric cancers
Amplification at 19q12 has been observed in multiple tumor types, while cyclin E1 (CCNE1) has been considered to be the key oncogene within this amplicon. We have previously applied …
19q12 amplified and non-amplified subsets of high grade serous …
2018年11月1日 · Tumors were classified by 19q12 amplification status and correlated to cyclin E1 and URI1 expression, BRCA1/2 germline mutation, FBXW7 and USP28 expression, and …
Detection of CCNE1/URI (19q12) amplification by in situ …
2017年2月2日 · 19q12 amplification status is a critical chemotherapy response determinant and therapeutic target in other cancer therapies. Primary treatment failure (platinum-based …
研究CCNE1扩增肿瘤的治疗靶点 - 中国核技术网 - ccnta.cn
2022年4月24日 · 据介绍，染色体19q12上ccne1基因座的扩增在多种肿瘤类型中普遍存在，尤其是在高级别浆液性卵巢癌、子宫肿瘤和胃食管癌中，其中高细胞周期蛋白e水平与基因组不稳定 …
Functional characterization of the 19q12 amplicon in grade III …
2012年3月20日 · The 19q12 locus is amplified in a subgroup of oestrogen receptor (ER)-negative grade III breast cancers. This amplicon comprises nine genes, including cyclin E1 (CCNE1), …