Results: 18 F-PFPN has an elevated radiochemical yield and was highly stable in vivo. In healthy volunteers, 18 F-PFPN was safe and well tolerated, and its effective absorbed dose was comparable to that of 18 F-FDG. In patient-based analysis, 18 F-PFPN uptake was higher than 18 F-FDG for both primary

2023年6月1日 · Introduction: Accurate diagnosis and prognostic risk assessment are paramount to reducing mortality of malignant melanoma (MM) patients, while conventional methods have their own demerits. 18 F-PFPN PET, a melanin-targeted imaging modality, showed superior diagnostic utility in MM.

目前临床上黑色素瘤的诊断和分期主要依靠视诊、组织病理学检查、ct、mri、18f-fdg pet/ct等。 这些检查方法虽有一定价值，但在精准分期、早期诊断等均有各自的不足之处。

Compared to 18 F-FDG, 18 F-PFPN demonstrated higher detection rates for ocular and orbital melanomas with minimal interference from surrounding tissues. This suggests that 18 F-PFPN could be a promising clinical diagnostic tool for distinguishing malignant melanoma from …

Purpose: Positron emission tomography (PET) using [18 F]-PFPN, a melanin-targeted imaging tracer, has excellent diagnostic performance in patients with melanoma. This study aimed to investigate its value in prognostication and determine predictors of progression-free survival (PFS) and overall survival (OS).

2022年2月3日 · Results: 18 F-PFPN has an elevated radiochemical yield and was highly stable in vivo. In healthy volunteers, 18 F-PFPN was safe and well tolerated, and its effective absorbed dose was comparable to that of 18 F-FDG. In patient-based analysis, 18 F-PFPN uptake was higher than 18 F-FDG for both primary tumors and nodal metastases.

18F-FDG PET has limited diagnostic applications in malignant mela-noma (MM). 18F-N-(2-(diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy) ethoxy)ethoxy)picolinamide (18F-PFPN) is a novel PET probe with high afnity and selectivity for melanin.

2023年2月5日 · 项目名称：靶向黑色素正电子分子影像探针18F-PFPN的研发及临床转化. 主要完成人：兰晓莉、张晓、盖永康. 恶性肿瘤的早期特异性诊断与精准评估是临床面临的重要问题和迫切需求。 黑色素瘤恶性程度高，预后差，目前诊断和分期主要依靠视诊、组织病理学检查、CT、MRI、18F-FDG PET显像等。 以上方法虽有一定价值，但在精准分期、早期诊断等均有各自的不足。 兰晓莉教授团队在国家级、省部级项目支持下，基于黑色素为靶点，历经10年，自主研 …

2023年5月16日 · Positron emission tomography (PET) using [18F]-PFPN, a melanin-targeted imaging tracer, has excellent diagnostic performance in patients with melanoma. This study aimed to investigate its value in prognostication and determine predictors of progression-free survival (PFS) and overall survival (OS).

2022年12月2日 · 本研究旨在探讨新型黑色素靶向成像模式 18F-PFPN PET 在黑色素瘤患者中的预后价值，并寻找无进展生存期 (PFS) 和总生存期 (OS) 的独立预后因素。 将连续入组接受 18F-PFPN 和 18F-FDG PET 扫描的临床高度疑似或确诊黑色素瘤患者。 患者的 PET 图像、临床特征和随访信息将被收集用于预后分析。 本研究计划将样本量设置为 100 个案例。 黑色素瘤是一种具有高死亡率的侵袭性恶性肿瘤。 准确的诊断和预后风险评估对于黑色素瘤的临床管理至关重 …