12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a hydroxyl residue at carbon 12 and a 5 Z, 8Z,10 E,14 Z cis–trans configuration (Z=cis, E=trans) in its four double bonds.

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid is a metabolite generated from arachidonic acid by 12S-type arachidonate 12-lipoxygenase in platelets. 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12 (S)-HETE) may be involved in inflammation and pruritus. A lipoxygenase metabolite of ARACHIDONIC ACID.

Many studies have demonstrated that 12-LOXs and their eicosanoid metabolite 12-hydroxyeicosatetraenoate (12-HETE), have significant pathological implications in inflammatory diseases.

2022年6月21日 · Elevations in 12-HETE have been observed in patients 24–40 hours post-MI 120. 12/15-LOX appears to be the major source of 12(S)-HETE since both inhibition and genetic manipulation of 12/15-LOX has been shown to alter cardiac function and inflammation post MI.

12(S)-HETE: The predominant lipoxygenase product of mammalian platelets. CAS Number: 54397-83-0. Synonym: 12(S)-Hydroxyeicosatetraenoic Acid. Purity: ≥98%.

The 12-lipoxygenase product 12S-HETE acts by the GPR31 receptor and promotes tumor cell proliferation and metastasis and could therefore be a promising target in cancer therapy. It may also be involved as a proinflammatory mediator in diabetes. In contrast, 15S-HETE may have a protective effect in cancer.

12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway [1].12-HETE has both anti-thrombotic and pro-thrombotic effects [2]. 12-HETE is a neuromodulator [3].

12(S)-HETE is a HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds. It has a role as a pro-angiogenic agent and a human metabolite. It is a HETE and a (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid. It is a conjugate acid of a 12(S)-HETE(1-). It is an enantiomer of a 12(R)-HETE.

2024年11月5日 · Here, we show for the first time the platelet-specific oxidized lipid, 12-HETE, is stable in the blood, is elevated in patients at risk for thrombosis, and demonstrates greater sensitivity in detecting platelet activation.

ChemSpider record containing structure, synonyms, properties, vendors and database links for 12-HETE, ZNHVWPKMFKADKW-UHFFFAOYSA-N