The Drosophila embryonic protein SNAI1, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm.

2024年12月25日 · SNAI1 (Snail Family Transcriptional Repressor 1) is a Protein Coding gene. Diseases associated with SNAI1 include Cercarial Dermatitis and Adenomyosis. Among its related pathways are Cell junction organization and Regulation of …

Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and survival, two processes central in cancer ...

Snail是近年发现的锌指转录因子，属于转录因子中的Snail超家族成员。 其第一次是在果蝇中被描述，Snail突变的果蝇胚胎表现为原肠胚缺陷，经证实与E-cadherin下调有关 [4]。

上皮-间充质转化 (EMT)是一种生物学过程，非运动的、极化的上皮细胞经历一系列的生化改变，成为具有侵袭能力、抗凋亡和 细胞外基质 (ECM)成分生物合成改变的运动的、非极化的间充质细胞。 上皮细胞和间充质细胞的形态和组织结构不同。 在典型的上皮细胞中，细胞是单层的或多层的。 多层结构是通过细胞间的相互作用维持的，包括紧密连接、缝隙连接、黏附连接、桥粒和ECM的相互作用。 这些连接和相互作用阻碍了单层上皮内单个细胞的运动。 间充质细胞很少与周围细 …

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.

2016年6月15日 · The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors.

2021年1月19日 · It has been increasingly recognized that SNAIL1 and SNAIL2, as major EMT-inducers, might also be involved in drug resistance of cancer cells. We sought to determine a relation between SNAIL1/2, E-cadherin and N-cadherin expression, as well as ovarian cancer cells' resistance to cisplatin and EMT markers' level.

2021年6月23日 · Snail1是上皮细胞向间充质细胞转化和癌症相关成纤维细胞 (CAF)活化所必需的转录因子。 除此之外，肿瘤内皮细胞也表达Snail1。 在这里，作者已经揭开了Snail1在肿瘤发生背景下在该组织中的作用。 在本研究中作者产生了内皮特异性的、可诱导的Snail1缺失的转基因小鼠。 将该小鼠系与发生乳腺肿瘤的MMTV-PyMT小鼠杂交，研究Snail1缺失内皮的后果。 Snail1是上皮细胞向间充质细胞转化和癌症相关成纤维细胞(CAF)活化所必需的转录因子。 除此之外， …