Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with …

Since that time, several case reports and case series have linked aldosterone antagonism in heart failure with life-threatening hyperkalemia, especially in combination with ACE inhibitors or …

The development of eplerenone, a selective aldosterone receptor blocker with greater specificity for the mineralocorticoid receptor, less than 1% affinity for the progesterone receptor, and less ...

Am J Health Syst Pharm. 2006;63(1):49-58 ...

Place in Therapy. In the absence of contraindications, an aldosterone antagonist should be offered to patients with NYHA class III or IV heart failure and to patients after an MI with left ...

Aldosterone acts in the distal nephron to increase sodium and water retention and excrete potassium. Angiotensin II also has cellular effects that promote growth factors, migration, …

Aldosterone antagonists (spironolactone and epleronone) have additional antihypertensive effects, especially at doses used for HF. They are indicated for patients with stage C and …

2017年7月25日 · Novel findings show a link between the steroid hormone aldosterone and a risk for alcohol use disorder, underscoring the role of neuroendocrine mechanisms in alcohol …

Before initiation of spironolactone therapy, renin-aldosterone status was characterized in terms of plasma-renin activity and 24-hour urinary aldosterone excretion.

2018年9月7日 · Increased levels of aldosterone are independently associated with a greater risk of type 2 diabetes, with the effects particularly notable in certain ethnic groups including …