c-Jun, the most extensively studied protein of the activator protein-1 (AP-1) complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival, tumorigenesis and tissue morphogenesis.

2025年3月30日 · JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Breast Cancer and Hematologic Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

The concentrations of c-Jun determine the positive and negative regulation of hARE-induced CAT expression. Interestingly, with a small increase in the concentration, c-Jun can heterodimerize with Nrf1 and Nrf2 to form positive regulatory complexes (Nrf1+c-Jun and Nrf2+c-Jun).

2019年12月4日 · Here we show that CAR T cells engineered to overexpress the canonical AP-1 factor c-Jun have enhanced expansion potential, increased functional capacity, diminished terminal differentiation...

2021年3月23日 · Here, we identified c-Jun and JunB as essential for cDC1 fate specification and function.

We show that in fibroblasts, c-Jun is required for progression through the G1 phase of the cell cycle; c-Jun-mediated G1 progression occurs by a mechanism that involves direct transcriptional control of the cyclin D1 gene, establishing a molecular link between growth factor signaling and cell cycle regulators.

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a paradigm for transcriptional response to extracellular signaling, whose components are basic-Leucine Zipper (bZIP) transcription factors of the Jun, Fos, activating transcription factor (ATF), ATF-like (BATF) and Jun dimerization protein 2 (JDP2) gene ...

c-Jun, a member of the activation protein 1 (AP-1) family of transcription factors, has been implicated in the regulation of many important biological processes including cell cycle progression, transformation, differentiation, and apoptosis.

Cotranslated c-Jun and c-Fos proteins bind 25 times more efficiently to the AP-1 DNA site as a heterodimer than does the c-Jun homodimer. These experiments suggest that in growth factor—stimulated cells c-Jun binds DNA as a dimer with c-Fos as its natural partner.

C-Jun is the most potent transcriptional activator whereas Fos proteins cannot homodimerise but form heterodimers with Jun proteins [224]. The AP-1 motif in the MMP-9 gene is considered by some to be the most important for its expression [201,211] .