Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated ... - PubMed
Acyl-CoA thioesterases (ACOTs) constitute a family of enzymes that hydrolyze fatty acyl-CoAs to form FFA and CoA. Although biochemically and biophysically well characterized, the metabolic functions of these enzymes remain incompletely understood.
The emerging role of acyl-CoA thioesterases and acyltransferases …
2012年9月1日 · Acyl-CoA thioesterases (ACOTs) catalyze the hydrolysis of acyl-CoA esters to produce the free fatty acid and CoASH (the figure shows stearoyl-CoA, resulting in the production of stearic acid and CoASH).
Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated …
Acyl-CoA thioesterases constitute a family of enzymes that hydrolyze fatty acyl-CoAs to form FFA and CoA. Although biochemically and biophysically well characterized, the metabolic functions of these enzymes remain incompletely understood.
Acyl-CoA thioesterase 7 is involved in cell cycle progression via ...
2017年5月18日 · Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the ACOT family that catalyzes hydrolysis of fatty acyl-CoAs to free fatty acids and CoA-SH. However, canonical and non-canonical functions...
Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of ...
2017年7月1日 · Acyl-CoA thioesterases (ACOTs) constitute a family of enzymes that hydrolyze fatty acyl-CoAs to form FFA and CoA. Although biochemically and biophysically well characterized, the metabolic functions of these enzymes remain incompletely understood.
Functional and structural properties of mammalian acyl …
2010年10月1日 · Acyl-CoA thioesterase 6 (Acot6) is a peroxisomal thioesterase that has been characterized as exhibiting a high specificity for the methyl-branched fatty acids phytanoyl-CoA (3,7,11,15-tetramethylhexadecanoyl-CoA) and pristanoyl-CoA (2,6,10,14-tetramethylpentadecanoyl-CoA) [7], [22].
Metabolic engineering strategies to produce medium-chain
2022年3月25日 · In microbes, plant acyl-ACP thioesterases can be leveraged to produce free fatty acids of desired chain length. Additional genetic modifications are needed to enable the conversion of the...
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism
Conversely, acyl-CoAs can be hydrolyzed by a family of acyl-CoA thioesterases (ACOT). Here, we have determined the transcriptional regulation of all ACS and ACOT enzymes across tissues and in response to metabolic perturbations.
Structural basis for recruitment of tandem hotdog domains in acyl-CoA ...
2007年6月19日 · Acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoA to free fatty acid and CoA and thereby regulate lipid metabolism and cellular signaling. We present a comprehensive structural and functional characterization of mouse acyl …
Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple …
Hepatic acyl-CoA thioesterase 1 (ACOT1) catalyzes the conversion of acyl-CoAs to fatty acids (FAs) and CoA. We sought to determine the role of ACOT1 in hepatic lipid metabolism in C57Bl/6J male mice 1 week after adenovirus-mediated Acot1 knockdown.
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