Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. [1] It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1.

Wee1激酶 是一种高度保守的细胞周期调节蛋白，在细胞周期调控和 DNA损伤修复 中发挥重要作用。 关于WEE1及其功能. Wee1激酶是丝氨酸/苏氨酸蛋白激酶家族的重要成员之一，最早发现于裂殖酵母中,主要由N-端结构域、中心激酶结构域和1个短的C-端结构域组成。

2022年11月6日 · ZN-c3是一款口服的Wee1抑制剂，目前由Zentalis和辉瑞共同开发，旨在诱导癌细胞中的合成致死，目前正在开发用于晚期实体瘤。

2024年7月19日 · WEE1（Wee1-like protein kinase）是最早发现于裂殖酵母中的一种核激酶，属于丝氨酸/苏氨酸蛋白激酶家族成员，是细胞周期进程的关键调节因子。 WEE1通过抑制周期蛋白依赖性激酶1（Cyclin-dependent kinase 1，CDK1）来抑制细胞进入有丝分裂，从而影响细胞大小。

2025年3月30日 · WEE1 (WEE1 G2 Checkpoint Kinase) is a Protein Coding gene. Diseases associated with WEE1 include Breast Cancer and Ciliary Dyskinesia, Primary, 20. Among its related pathways are Mitotic G1 phase and G1/S transition and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

2024年3月7日 · Here, the authors perform a multi-omics analysis of hyperthermia-treated ovarian cancer cells, show that CDK1 becomes hyperactivated and regulates signalling upon hyperthermia, and identify WEE1...

Wee1是丝氨酸/苏氨酸蛋白激酶家族中的一员，具有96kDa的分子量，可以使CDK1的Thr14和Tyr15磷酸化而抑制CDK1激酶活性，从而抑制细胞进入有丝分裂。 网页 新闻 贴吧 知道 网盘 图片 视频 地图 文库 资讯 采购 百科

High expression of WEE1 is associated with poor prognosis and Wee1 silencing increases tumor cell death; Wee1 represents a potential therapeutic target in melanoma Immunohistochemistry and Western blotting

2022年1月1日 · WEE1 is a critical target for inhibitors, which can enhance the efficacy of other types of conventional therapy and overcome the resistance to conventional treatment. WEE1, which primarily functions by inhibiting the CDK1-cyclinB complex, also affects the function of many other proteins because of this activity.

2024年1月17日 · WEE1 is a crucial kinase involved in the regulation of G2/M checkpoint within the cell cycle. This article aims to comprehensively review the existing knowledge on the implication of WEE1 as a therapeutic target in tumor progression and drug resistance.