Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. [5] VCAM-1 functions as a cell adhesion molecule.

VCAM-1 is a key cell adhesion molecule involved in inflammation that is closely implicated in various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer . VCAM-1 is a potential therapeutic target in immunological disorders and cancer.

2025年3月30日 · Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include integrin binding and primary methylamine oxidase activity .

2023年7月15日 · Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules (CAM) with a crucial role in mediating the strong adherence of leukocytes to endothelial cells in numerous acute as well as chronic diseases.

The vascular cell adhesion molecule VCAM-1 was originally identified as a cytokine-inducible adhesion molecule on human endothelial cells, mediating the binding to leukocytes and melanoma cells (178,203,204). VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207).

E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured in serum from hypertensive patients with LV hypertrophy Strongly expressed in histological type II of rheumatoid arthritis.

2023年8月1日 · VCAM-1 and ICAM-1 are integral membrane proteins that are broadly dispersed in an adult brain and have an impact on neurons, astrocytes, microglial cells, and cerebral vascular endothelial cells. Research clearly shows that VCAM-1 and ICAM-1 serve as signal transducers in the CNS.

VCAM-1 is an immunoglobulin-like adhesion molecule expressed on activated endothelial cells . VCAM-1 binds to α 4 β 1 integrin, which is constitutively expressed on lymphocytes, monocytes, and eosinophils. Interestingly, VCAM-1 can mediate both rolling-type adhesion and firm adhesion, depending on the avidity status of α 4 β 1 integrin ...

2021年9月1日 · The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically participates in the adhesion and transmigration of leukocytes to the interstitium during inflammation.

There is emerging evidence that VCAM-1 is more than a biomarker and may be a promising therapeutic target for vascular diseases. While there are neutralizing antibodies that allow preclinical research, the development of pharmacological tools to activate or inhibit this protein are required to thoro …