2024年2月6日 · A spatial and single-cell atlas of the mouse female reproductive tract details transcriptional and cellular abundance changes occurring across estrous cycling, pregnancy, and aging, revealing how cycling-related remodeling contributes to inflammation and …

2023年7月29日 · Estrogens play important roles in uterine growth and homeostasis through estrogen receptors (ESR1 and ESR2). To address the role of ESR1-mediated tissue events in the murine uterus, we analyzed...

Our data provide a valuable resource for deciphering the molecular mechanism underlying uterine receptivity in mice. In this study, by using the state‐of‐the‐art single‐cell RNA‐seq approach, we resolved all cell types of the pre‐receptive and the receptive mouse uterus at single‐cell resolution.

2024年1月5日 · This study presents the first longitudinal imaging data that focuses on revealing anatomical alterations of the vagina, cervix, and uterine horns during pregnancy and postpartum using the mouse...

2020年9月3日 · In the present study, Wdr13 knockout female mice developed benign proliferative epithelium that progressed into EH at around one year of age accompanied by an increase in body weight and elevated...

2022年5月20日 · We used published scRNA-seq data of two C57BL/6J mice uteri to build an integrated cell atlas from the regenerative endometrium to the maturational endometrium, and elucidated the transitions that happened in epithelial cells, stromal cells, and immune cells during the estrous cycle, hoping to provide new insights into cell dynamics in the ...

2022年2月5日 · We revealed 23 distinct cell clusters, including 5 stromal cell clusters, 2 epithelial cell clusters, 1 smooth muscle cell cluster, 2 pericyte clusters, 4 endothelial cell clusters, and 9 immune cell clusters. Through data analysis, we identified differentially expression changes in all uterine cell types upon embryo implantation.

Here, we aimed to decipher mouse uterine receptivity for embryo implantation at single-cell resolution. Materials and methods: Single-cell RNA sequencing was performed for the pre-receptive and the receptive mouse uterus. Gene expression profiles in luminal epithelium and glandular epithelium were validated by comparing against a published ...

2023年7月31日 · In this study, we develop an engineered uterus that reconstitutes key properties of the mouse uterine environment at implantation, in order to dissect the potential role and mechanisms of embryo‐uterus interaction and tissue …

In this article, we report the generation of a new iCre knock-in mouse line, in which iCre is expressed from endogenous lactoferrin (Ltf) promoter. Ltf-iCre mice primarily direct recombination in the uterine epithelium in adult females and in immature females after estrogen treatment.