AD最新综述：衰老、脑炎症和寡聚tau驱动AD认知能力下降
2024年1月26日 · Tau低聚物（TauO）——神经毒性最强的Tau类型——已知会诱导衰老和SASP，从而促进神经病理学、炎症、氧化应激、突触功能障碍、神经元死亡和认知功能障碍 …
Tau441蛋白在阿尔茨海默症（AD）中应用 - 知乎 - 知乎专栏
tau蛋白是阿尔茨海默症（AD）等一系列神经退行性疾病的重点研究对象。过度磷酸化导致tau蛋白从微管上脱离、聚集形成可溶的tau蛋白寡聚体（Tauo），进而在神经元内形成神经纤维缠 …
Tau oligomer induced HMGB1 release contributes to cellular …
In the present study, we report that (1) TauO-associated astrocytes exhibit markers of senescence-associated cell-cycle arrest (p16 INK4A), senescence-associated DNA damage …
Nature | 基于结构的tau蛋白病分类 - 知乎 - 知乎专栏
综上， 本文通过解析8种常见的tau蛋白病中tau蛋白细丝的结构，结合已报道的结构，提出了基于tau蛋白折叠的tau蛋白病的分类方式，并依此鉴定出了一种新的tau蛋白病。 虽然潜藏于tau蛋 …
Internalization mechanisms of brain-derived tau oligomers from …
2020年5月4日 · Using brain-derived tau oligomers (BDTOs) from AD, PSP, and DLB patients, we investigated neuronal internalization mechanisms of BDTOs, including the heparan sulfate …
Tau oligomer induced HMGB1 release contributes to cellular ... - PubMed
2021年7月20日 · Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal …
Senescence, brain inflammation, and oligomeric tau drive
2023年10月9日 · HIGHLIGHTS: Senescence, oligomeric Tau (TauO), and brain inflammation accelerate the aging process and promote the progression of tauopathies, including …
Lysine 63-linked ubiquitination of tau oligomers contributes to the ...
Soluble tau oligomers (TauO) are the most neurotoxic tau species that propagate pathology and elicit cognitive deficits, but whether ubiquitination contributes to tau formation and spreading is …
Senescence, brain inflammation, and oligomeric tau drive …
2023年10月9日 · Tau oligomers (TauO)—the most neurotoxic tau species—are known to induce senescence and the SASP, which subsequently promote neuropathology, inflammation, …
<br>衰老、脑部炎症和寡聚 tau 蛋白导致阿尔茨海默病认知能力下 …
Tau 寡聚物 (TauO) 是最具神经毒性的 tau 物种，已知会诱导衰老和 SASP，从而促进神经病理学、炎症、氧化应激、突触功能障碍、神经元死亡和认知功能障碍。