Tumor necrosis factor (TNF) receptor-2 (TNFR2) affects tumor development and metastasis in several ways. TNFR2 promotes tumor immune escape by virtue of its ability to stimulate various immune suppressive cell types, e.g., regulatory T-cells (Tregs) ...

Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities.

To provide a safer and more precise treatment approach for tumor immunotherapy, we need to explore the specific mechanism of TNFR2 in the tumor microenvironment and accurately understand the expression level of TNFR2 and the ratio of …

There is compelling evidence that tumor necrosis factor (TNF) receptor type II (TNFR2) plays a decisive role in the activation and expansion of Tregs and other types of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs). Furthermore, TNFR2 is also expressed by some tumor cells.

2019年1月10日 · Increasing evidence suggests that thymus-derived, natural regulatory T cells (nTreg) express a remarkably high level of TNF Receptor 2 (TNFR2) and TNFα modulates the number or function of nTreg...

Tumor necrosis factor (TNF) receptor 2 (TNFR2) is a signaling molecule found on the surface of a subset of potent regulatory T cells (T reg s) that can activate the proliferation of these cells through nuclear factor kappa B (NF-κB).

2017年10月11日 · Here we introduce TNFR2, discuss its role in T reg expansion and contraction, and summarize emerging approaches to putatively target TNFR2 in certain cancers.

2022年5月25日 · Based on a brief summary of TNFR2 signaling and the immunoregulatory functions of TNFR2, we discuss here the main preclinical findings and insights gained with TNFR2 agonists and antagonists.

Here, we reviewed the activation mechanism of TNFR2 and its role in signal transduction in the tumor microenvironment. We summarized the expression and function of TNFR2 within different immune cells and the potential opportunities and challenges of targeting TNFR2 in immunotherapy.

Here, we review the role of the TNFR2 signaling pathway in tolerance and the equilibrium of T cell responses and its connections with oncogenesis. We analyze recent discoveries concerning the targeting of TNFR2 in cancer, as well as the advantages, limitations, and …