Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin(IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor.

2025年3月30日 · STAT6 (Signal Transducer And Activator Of Transcription 6) is a Protein Coding gene. Diseases associated with STAT6 include Hyper-Ige Syndrome 6, Autosomal Dominant, With Recurrent Infections and Hemangiopericytoma, Malignant .

Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is ...

2021年11月26日 · There are 4 members in the JAK family: JAK1, JAK2, JAK3, and TYK2. The STAT family comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6. We introduce them by family. JAK...

2021年7月1日 · Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin (IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor.

2024年1月17日 · Germline heterozygous GOF STAT6 variants have been recently discovered to cause a broad and severe human clinical phenotype of asthma, atopic dermatitis, food and drug allergies, eosinophilic gastrointestinal disease, as well as skeletal and vascular anomalies.

STAT6 is considered to be the key of the IL-4 signaling pathway and a driver of Th2 cell differentiation . However, in the absence of IL-4R, Treg cells lose their regulatory function to suppress eosinophil infiltration in the lung after adoptive transfer into sensitized mice .

Our STAT6 degraders showed potent STAT6 degradation and IL-4/IL-13 functional inhibition in human whole blood, were orally bioavailable in multiple preclinical species, and were able to deplete STAT6 in vivo.

2025年3月8日 · In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses.

STAT6-repressed enhancers are characterized by reduced chromatin accessibility, eRNA expression, LDTF, and p300 binding. IL-4-STAT6-mediated repression limits the inflammatory responsiveness including inflammasome activation, IL-1β production, and pyroptosis.