2019年2月19日 · Hyper-activated STAT5 leads to the aberrant expression of its target genes including antiapoptotic, proliferative, and pro-inflammatory genes, favouring tumorigenesis.

STAT5 is a unique STAT family member, as there are two STAT5 proteins that are encoded for by separate genes. STATs 5A and 5B have both redundant and non-redundant functions that include the modulation of cell differentiation, lipid mobilization, lymphocyte development, and …

STAT5 critically mediates the biological actions of members of the γ(c) family of cytokines in the immune system. Essentially, STAT5 plays a critical role in the function and development of Tregs, and consistently activated STAT5 is associated with a suppression in antitumor immunity and an increase in proliferation, invasion, and survival of ...

2023年1月3日 · STAT5 is required to increase the expression of genes encoding enzymes involved in the glycolysis and oxidative phosphorylation pathways, and amino acid transporters, which are needed to support...

2000年5月25日 · The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane to the...

Signal transducer and activator of transcription 5 (STAT5) refer to two proteins that share 94% structural homology and are transcribed from separate genes, STAT5A and STAT5B. However, they are both essential in erythroid differentiation [5].

We report here that persistent activation of signal transducer and activator of transcription 5 (STAT5) in tumor-specific CD4 + T cells drives the development of polyfunctional T cells.

STAT5 plays a crucial role in the development of the mammary gland and the homeostasis of the immune system. However, in various cancers, aberrant STAT5 signalling promotes the expression of target genes, such as cyclin D, Bcl-2 and MMP-2, that result in increased cell proliferation, survival and metastasis.

2025年3月30日 · STAT5A (Signal Transducer And Activator Of Transcription 5A) is a Protein Coding gene. Diseases associated with STAT5A include Myeloproliferative Neoplasm and Chronic Leukemia. Among its related pathways are IL-9 …

2011年10月12日 · In normal development, STAT5 expression and activity are regulated by prolactin signaling with JAK2/ELF5, EGF signaling networks that include c-Src, and growth hormone, insulin growth factor, estrogen, and progesterone signaling pathways. In cancer, erythropoietin signaling can also regulate STAT5.