Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. [5] [6] SOCS1 orthologs [7] have been identified in several mammals for which complete genome …

2018年4月19日 · SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1, the most potent member of the family, can also …

2025年3月30日 · SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Autoinflammatory Syndrome, Familial, With Or …

2025年3月3日 · Lancet Rheumatology has published a population study of the rare suppressor of cytokine signalling 1 (SOCS1) insufficiency - an inborn error of immunity affecting the negative …

In this review, we describe the mechanism of SOCS1 action, focusing on the role of SOCS1 in autoimmunity and cancer, and discuss the potential for new SOCS1-directed cancer therapies …

SOCS1 is a negative feedback regulator of cytokine and growth factor receptor signaling, and plays an indispensable role in attenuating interferon gamma signaling. Studies on SOCS1 …

Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in tuberculosis.

2025年2月27日 · In 2020, suppressor of cytokine signalling 1 (SOCS1) insufficiency was added to the group of monogenetic immune dysregulatory disorders. 7–9 SOCS1 is a crucial negative …

The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of …

2007年5月18日 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathways. SOCS1 also …