SHP-1 作为 PTP 中重要的一员，是改变胞内磷酸化水平的关键因子，当外源性信号分子同胞膜上受体结合后激发受体分子二聚化，与受体耦联的两面神激酶（JAK）互相靠拢，通过彼此的酪 …

2024年12月2日 · SHP1和SHP2是非受体蛋白酪氨酸磷酸酶（nonreceptor protein tyrosine phosphatase）家族蛋白成员，对造血和免疫系统的正常发育和功能调节至关重要，同时在肿 …

2024年2月6日 · Here we demonstrate that inhibition of tyrosine phosphatase SHP-1 in LSCs increases their glycolysis and oxidative phosphorylation, enhancing their sensitivity to …

SHP-1 [protein tyrosine phosphatase, non-receptor type 6 (PTPN6)] is expressed by all mature haematopoietic lineages and at low levels, in a different isoform, by endothelial cells . There is …

2016年4月15日 · This review will discuss the potential value of SHP-1 inhibition in future tumour immunotherapy. Keywords: SHP-1; adoptive cell transfer; checkpoint inhibitors; protein …

SHP-1 or PTPN6 (previously also referred to as SH-PTP1, PTP1C, HCP, or Hcph) is expressed predominantly in hematopoietic cells of all lineages and all stages of maturation, while it is …

2024年4月21日 · Detailed studies have shown that SHP-1 regulates SHP2 expression, and SHP-1 and SHP2 are involved in macrophage M2 polarisation. SHP-1 inhibits HOXA10 and TGFβ2 …

2003年3月13日 · SHP-1, an SH2 domain-containing protein tyrosine phosphatase, is primarily expressed in hematopoietic cells and behaves as a key regulator controlling intracellular …

2023年4月11日 · During education, inhibitory receptors sequestered SHP-1, suggesting a model in which SHP-1 is prevented from accumulating at activating immune synapses between NK …

2018年8月15日 · Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1, also known as PTPN6) is a nonreceptor protein tyrosine phosphatase that acts as a negative …