A pyrin domain (PYD, also known as PAAD/DAPIN) is a protein domain and a subclass of protein motif known as the death fold, the 4th and most recently discovered member of the death …

NLRP3、AIM2、NLRC4 和 Pyrin 之间关键相互作用的发现代表了一种新的范式，有助于理解这些分子在先天性免疫和炎症小体生物学中的功能，并为 NLRP3、AIM2、NLRC4 和 Pyrin 介导 …

2023年11月27日 · The discovery of critical interactions among NLRP3, AIM2, NLRC4, and Pyrin represents a new paradigm in understanding the functions of these molecules in innate …

MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells …

2020年9月25日 · 核苷酸结合结构域、富含亮氨酸的重复序列和含热蛋白（pyrin）结构域的蛋白3（NLRP3）可被尼日利亚菌素nigericin）、细胞外ATP和尿酸单钠（MSU）晶体 ...

Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene …

2016年6月6日 · Pyrin forms an inflammasome when mutant or in response to bacterial modification of the GTPase RhoA. We found that RhoA activated the serine-threonine kinases …

Pyrin is a cytosolic protein encoded by the gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the …

Pyrin is a sensor within cells that detects disruptions in cellular balance caused by bacterial toxins, leading to the activation of the pyrin inflammasome involved in inflammatory responses. You …