PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions, PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in fibroblasts. Disruption of PU.1 in fibrotic fibroblasts leads to them returning into their resting state from pro-fibrotic fibroblasts.

PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on immune cell differentiation.

2010年6月3日 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein–protein interactions with ...

PU.1 is an E26 transformation-specific family transcription factor that is required for development of the immune system. PU.1 functions at both early and late stages of lymphoid and myeloid differentiation. At least 110 direct target genes of PU.1 have …

2020年1月21日 · Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing...

PU.1 is a member of the transcription factor family Ets that is expressed selectively on B cells, myeloid cells and macrophages. PU.1 regulates the expression of several genes, including those encoding immunoglobulins, receptors and enzymes.

2019年1月30日 · The transcription factor PU.1 is an essential regulator of the pro-fibrotic gene expression program in fibroblasts; PU.1 expression is upregulated in various fibrotic diseases, whereas ...

PU.1是ETS转录因子家族 (E26 transformation-specific family)的成员,在机体多种组织发育中发挥重要作用.近年来的研究发现,PU.1不仅在造血谱系的确定和分化中起作用,而且还在机体免疫,脂肪形成,组织纤维化,神经发育中发挥功能.在造血及免疫等系统中,PU.1与多个靶基因形成 ...

2023年11月17日 · PU.1的基本特征PU.1是一个能够结合DNA的、具有特异性和亚型选择性的转录因子。 它属于Ets家族（Etsfamily），包含一段无序的N端、一个DNA结合域、一个亚胺基末端、一个PNT结构体和一个可变的C端区域。

PU.1 is a member of the Ets family of transcription factors and activates target genes through the purine-rich PU-box (1). PU.1 plays a pivotal role in the differentiation of myeloid cells and lymphocytes and is expressed in several hematopoietic cells, including B lymphocytes, macrophages, neutrophils, mast cells, early erythroid cells, and ...