2023年4月14日 · Poly (ADP-ribose) polymerase inhibitors, also called PARP inhibitors, are targeted therapies that are used to treat cancer. PARP is a protein that has a role in cellular …

2024年4月3日 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) …

2020年9月9日 · PARP inhibitors (PARPi) were the first approved cancer drugs that specifically targeted the DNA damage response in BRCA1/2 mutated breast and ovarian cancers.

PARP inhibitors are a type of targeted cancer drug. They are a treatment for several types of cancer including ovarian, breast and prostate cancer. They are also in trials as a treatment for …

PARP (poly ADP-ribose polymerase) are proteins that bind to broken strands of DNA and recruit other proteins to repair damaged DNA. There are multiple pathways (controlled by multiple …

PARP inhibitors (PARPi), a cancer therapy targeting poly (ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept proposed …

2020年8月13日 · To provide recommendations on the use of poly (ADP-ribose) polymerase inhibitors (PARPis) for management of epithelial ovarian, tubal, or primary peritoneal cancer …

The introduction of PARP inhibitors (PARPi) in prostate cancer is a milestone and provides a pathway to hope in fighting this disease. It is the first time that drugs, based on the concept of …

2023年7月10日 · Poly (ADP-ribose) polymerase inhibitors (PARPi) have significantly changed the treatment landscape for tumours harbouring defects in genes involved in homologous repair …

2017年3月17日 · PARP inhibitors (PARPi), a cancer therapy targeting poly (ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a …