Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene …

2017年7月5日 · PARP1 is an abundant nuclear protein that post-translationally attaches a negatively charged polymer termed poly (ADP-ribose) (PAR) to itself and to multiple target …

PARP1 was first described by its role in the repair of alkylating agent-induced DNA base damages and also single strand breaks (SSBs). PARP1 is involved in base excision repair (BER) via …

2025年3月30日 · PARP1 (Poly (ADP-Ribose) Polymerase 1) is a Protein Coding gene. Diseases associated with PARP1 include Diphtheria and Fallopian Tube Carcinoma. Among its related …

Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base …

2025年2月8日 · PARP1 expression predicts PARP inhibitor sensitivity and correlates with metastatic potential and overall survival in melanoma. Functional genetic variation in 3'UTR of …

2024年5月17日 · DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co …

2024年5月28日 · Here, through live-cell imaging, we quantify the alterations in PARP1 dynamics and activity elicited by seven PARPis over a wide range of concentrations to deliver a unified …

2024年9月20日 · Poly (ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family, which modifies targets through ADP-ribosylation and plays key roles in a variety of …

2024年11月13日 · At molecular level, USP1 binds PARP1 to remove its K63-linked polyubiquitination and controls PARP1 chromatin trapping and PARylation activity, regulating …